The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach

Sabalić, Srećko; Kovačević, Dujo; Glavić, Željko; Buković, Damir; Despot, Albert; Fajdić, Josip; Lukač, Josip; Šešo, Ivana

Scientific paper - Original scientific paper

The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach

Collegium Antropologicum, 30 (2006), 4; 885-893. urn:nbn:hr:105:574813

Sabalić, Srećko; Kovačević, Dujo; Glavić, Željko; Buković, Damir; Despot, Albert; Fajdić, Josip; Lukač, Josip; Šešo, Ivana

Cite this document

APA 6th Edition

Sabalić, S., Kovačević, D., Glavić, Ž., Buković, D., Despot, A., Fajdić, J. ... Šešo, I. (2006). The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach. Collegium Antropologicum, 30. (4), 885-893. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:574813

MLA 8th Edition

Sabalić, Srećko, et al. "The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach." Collegium Antropologicum, vol. 30, no. 4, 2006, pp. 885-893. https://urn.nsk.hr/urn:nbn:hr:105:574813

Chicago 17th Edition

Sabalić, Srećko, Dujo Kovačević, Željko Glavić, Damir Buković, Albert Despot, Josip Fajdić, Josip Lukač and Ivana Šešo. "The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach." Collegium Antropologicum 30, no. 4 (2006): 885-893. https://urn.nsk.hr/urn:nbn:hr:105:574813

Harvard

Sabalić, S., et al. (2006) 'The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach', Collegium Antropologicum, 30(4), pp. 885-893. Available at: https://urn.nsk.hr/urn:nbn:hr:105:574813 (Accessed 16 July 2024)

Vancouver

Sabalić S, Kovačević D, Glavić Ž, Buković D, Despot A, Fajdić J, and sur.. The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach. Collegium Antropologicum [Internet]. 2006 December [cited 2024 July 16];30(4):885-893. Available at: https://urn.nsk.hr/urn:nbn:hr:105:574813

IEEE

S. Sabalić, et al., "The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach", Collegium Antropologicum, vol. 30, no. 4, pp. 885-893, December 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:574813. [Accessed: 16 July 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:574813

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Metadata

Title (english)	The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach
Author	Srećko Sabalić
Author	Dujo Kovačević
Author	Željko Glavić
Author	Damir Buković
Author	Albert Despot
Author	Josip Fajdić
Author	Josip Lukač
Author	Ivana Šešo
Author's institution	University of Zagreb School of Medicine
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	The total number of 542 patients with colorectal cancer surgery have been analyzed in order to estimate the effect of receiving transfusion local recurrences, and the disease free - survival. It should be examined whether there are changes in general immunity indicators which would be connected with perioperative transfusion. A significant connection has been found between local recurrences and blood transfusion (p<0.0001), the most noticeable being in Dukes A (p =0.045), localization on rectum (p=0.036). The receiving of blood transfusion is linked significantly with disease free - survival reduction (p =0.0068; log rank), the most significant being in Dukes A stage (p =0.0123; log rank) and with localization on rectum (p=0.0231). The analysis of general immunity indicators has shown significant immunocompromitation of patients just before the surgery and this could have effect on immunomodulation caused by transfusion and just as on the treatment prognosis of colorectal carcinoma.
Abstract (croatian)	Analizirano je 542 bolesnika operiranih zbog kolorektalnog karcinoma radi procijene utjecaja primanja transfuzije na pojavu lokalnih recidiva i na period bez bolesti – preživljavanje. Istražene su promjene u pokazateljima opće imunosti i njihovu moguću povezanost sa perioperacijskom transfuzijom. Nađena je značajna povezanost pojave lokalnih recidiva i primanja transfuzije (p<0,0001), najizraženije kod Dukesa A (p=0,045), lokalizacije na rektumu i rektosigmoidu (p=0,036). Količina transfuzije najviše je povezana sa pojavom lokalnih recidiva kod Dukesa A (p=0,008), lokalizacije na rektumu (p=0,008). Primanje transfuzije (p=0,0123; log rank) značajno je povezano sa skraćenjem perioda bez bolesti – preživljavanje, najznačajnije kod Dukes A stadija (p=0,0123; log rank), te pri lokalizaciji na rektumu (p=0,0231; long rank). Analizom pokazatelja opće imunosti uočena je značajna imunokompromitacija bolesnika prije same operacije, što bi moglo djelovati na stupanj imunomodulacije uzrokovane transfuzijom, a tim i na prognozu liječenja kolorektalnog karcinoma.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Collegium Antropologicum
Numbering	vol. 30, no. 4, pp. 885-893
p-ISSN	0350-6134
URN:NBN	urn:nbn:hr:105:574813
Publication	2006-12
Document URL	https://hrcak.srce.hr/27685
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2024-03-28 11:02:41