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Scientific paper - Original scientific paper
Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia
Collegium Antropologicum, 32 (2008), 2; 565-570. urn:nbn:hr:105:181343
Tikvica, Ana; Kušan Jukić, Marija; Pintarić, Ivana; Medić, Marijana; Hudiček-Martinčić, Gordana; Košec, Vesna; Salihagić-Kadić, Aida

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Tikvica, A., Kušan Jukić, M., Pintarić, I., Medić, M., Hudiček Martinčić, G., Košec, V. & Salihagić Kadić, A. (2008). Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia. Collegium Antropologicum, 32. (2), 565-570. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:181343

Tikvica, Ana, et al. "Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia." Collegium Antropologicum, vol. 32, no. 2, 2008, pp. 565-570. https://urn.nsk.hr/urn:nbn:hr:105:181343

Tikvica, Ana, Marija Kušan Jukić, Ivana Pintarić, Marijana Medić, Gordana Hudiček Martinčić, Vesna Košec and Aida Salihagić Kadić. "Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia." Collegium Antropologicum 32, no. 2 (2008): 565-570. https://urn.nsk.hr/urn:nbn:hr:105:181343

Tikvica, A., et al. (2008) 'Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia', Collegium Antropologicum, 32(2), pp. 565-570. Available at: https://urn.nsk.hr/urn:nbn:hr:105:181343 (Accessed 21 August 2024)

Tikvica A, Kušan Jukić M, Pintarić I, Medić M, Hudiček Martinčić G, Košec V, and sur.. Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia. Collegium Antropologicum [Internet]. 2008 June [cited 2024 August 21];32(2):565-570. Available at: https://urn.nsk.hr/urn:nbn:hr:105:181343

A. Tikvica, et al., "Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia", Collegium Antropologicum, vol. 32, no. 2, pp. 565-570, June 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:181343. [Accessed: 21 August 2024]

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Metadata
Title (english)Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia
AuthorAna Tikvica
AuthorMarija Kušan Jukić
AuthorIvana Pintarić
AuthorMarijana Medić
AuthorGordana Hudiček-Martinčić
AuthorVesna Košec
AuthorAida Salihagić-Kadić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
In order to study the possible role of nitric oxide (NO) in the human placenta, we measured the concentration of its stable metabolite nitrite (NO2-) in the placentas of women with normal pregnancies and those from pregnancies complicated by intrauterine growth restriction (IUGR) with or without fetal hypoxia. We have measured nitrites by the Griess reaction in 15 placentas from IUGR pregnancies and 12 controls. Cerebroumbilical ratio (C:U) was recorded by color Doppler ultrasound and values below 1 were considered to be a predictor for fetal hypoxia. NO2- levels measured in pathological placentas were increased for at least 93% as compared to control. Subjects from pregnancies complicated by IUGR and fetal hypoxia had increased NO2- as compared to the placentas from pregnancies with IUGR and normal fetal oxygenation. NO production in placenta is increased in pregnancies with IUGR. This effect is more pronounced in those with compromised fetal oxygenation.
Abstract (croatian)
Kako bismo istražili moguću ulogu dušikovog monoksida (NO) u ljudskoj posteljici mjerili smo koncentracije njegovih stabilnih metabolita nitrita (NO2) u posteljicama žena s normalnim trudnoćama, kao i kod onih s fetalnim zastojem u rastu sa ili bez hipoksije. Koncentraciju nitrita određivali smo pomoću Griessove reakcije kod 12 posteljica iz trudnoća kompliciranih zastojem u rastu, te kod 12 kontrola. Cerebroumbilikalni omjer (C/U) određivan je pomoću ultrazvučnog obojenog Dopplera, a njegove vrijednosti manje od 1 smatrane su dobrim pokazateljima fetalne hipoksije. Vrijednosti NO2 – mjerene u posteljicama iz patoloških trudnoća su najmanje za 93 % uvećane u usporedbi s kontrolom. Štoviše, posteljice iz trudnoća s fetalnim zastojem u rastu i fetalnom hipoksijom imaju znatno veće koncentracije NO2 – u usporedbi s posteljicama s fetalnim zastojem u rastu, ali s normalnom fetalnom oksigenacijom. Stvaranje dušikovog monoksida je povećano u posteljicama trudnoća s fetalnim zastojem u rast. Taj je efekt još izraženiji ako je, uz zastoj u rastu, kompromitirana i fetalna oksigenacija.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. 2, pp. 565-570
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:181343
Publication2008-06
Document URLhttps://hrcak.srce.hr/27210
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:05:13