prikaz prve stranice dokumenta The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects
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Scientific paper - Original scientific paper
The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects
Neuroscience Letters, 462 (2009), 1; 45-48. https://doi.org/10.1016/j.neulet.2009.06.080
Pivac, Nela; Nedić, Gordana; Mustapić, Maja; Babić, Ana; Stipčević, Tamara; Borovečki, Fran; Hajnšek, Sanja; Mück-Šeler, Dorotea

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Pivac, N., Nedić, G., Mustapić, M., Babić, A., Stipčević, T., Borovečki, F. ... Mück Šeler, D. (2009). The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects. Neuroscience Letters, 462. (1), 45-48. doi: 10.1016/j.neulet.2009.06.080

Pivac, Nela, et al. "The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects." Neuroscience Letters, vol. 462, no. 1, 2009, pp. 45-48. https://doi.org/10.1016/j.neulet.2009.06.080

Pivac, Nela, Gordana Nedić, Maja Mustapić, Ana Babić, Tamara Stipčević, Fran Borovečki, Sanja Hajnšek and Dorotea Mück Šeler. "The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects." Neuroscience Letters 462, no. 1 (2009): 45-48. https://doi.org/10.1016/j.neulet.2009.06.080

Pivac, N., et al. (2009) 'The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects', Neuroscience Letters, 462(1), pp. 45-48. doi: 10.1016/j.neulet.2009.06.080

Pivac N, Nedić G, Mustapić M, Babić A, Stipčević T, Borovečki F, and sur.. The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects. Neuroscience Letters [Internet]. 2009 October 02 [cited 2024 November 29];462(1):45-48. doi: 10.1016/j.neulet.2009.06.080

N. Pivac, et al., "The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects", Neuroscience Letters, vol. 462, no. 1, pp. 45-48, October 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:336456. [Accessed: 29 November 2024]

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Metadata
Title (english)The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects
AuthorNela Pivac
AuthorGordana Nedić
AuthorMaja Mustapić
AuthorAna Babić
AuthorTamara Stipčević
AuthorFran Borovečki
AuthorSanja Hajnšek
AuthorDorotea Mück-Šeler
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
A polymorphism in the serotonin transporter gene (5-HTTLPR) is frequently studied for association with antidepressant treatment response, different personality traits, and psychiatric disorders. Baseline platelet serotonin (5-HT) concentration has been proposed to indicate a good or a poor treatment response to antidepressant drugs and to be associated with particular symptoms in psychiatric disorders. The aim of the study was to elucidate the genotype-phenotype relationship between platelet 5-HT concentration and 5-HTTLPR in healthy subjects. The frequency of 5-HTTLPR genotypes and alleles, as well as platelet 5-HT concentration was evaluated in 434 male and 86 female unrelated healthy medication-free Caucasian subjects of Croatian origin. A two-way ANOVA revealed no significant difference in platelet 5-HT concentration subdivided according to the particular 5-HTTLPR genotype, no significant effect of sex, no significant effect of genotype, and no significant interaction between sex and genotype on platelet 5-HT concentration. In addition, one-way ANOVA did not detect significant effects of homozygous S/S genotype, or homozygous L/L genotype on platelet 5-HT concentration. Our results showed a lack of significant association between platelet 5-HT concentration and 5-HTTLPR variants, suggesting that there is no functional relationship between 5-HTTLPR alleles and platelet 5-HT concentration in the large groups of healthy male and female medication-free Caucasian subjects, free of neuro-psychiatric disorders.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleNeuroscience Letters
Numberingvol. 462, no. 1, pp. 45-48
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2009.06.080
URN:NBNurn:nbn:hr:105:336456
Publication2009-10-02
Document URLhttps://doi.org/10.1016/j.neulet.2009.06.080
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:26:34