prikaz prve stranice dokumenta Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series
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Scientific paper - Original scientific paper
Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series
Croatian Medical Journal, 51 (2010), 1; 32-39. https://doi.org/10.3325/cmj.2010.51.32
Polašek, Ozren; Jerončić, Iris; Mulić, Rosanda; Klišmanić, Zorana; Pehlić, Marina; Zemunik, Tatijana; Kolčić, Ivana

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Polašek, O., Jerončić, I., Mulić, R., Klišmanić, Z., Pehlić, M., Zemunik, T. & Kolčić, I. (2010). Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series. Croatian Medical Journal, 51. (1), 32-39. doi: 10.3325/cmj.2010.51.32

Polašek, Ozren, et al. "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series." Croatian Medical Journal, vol. 51, no. 1, 2010, pp. 32-39. https://doi.org/10.3325/cmj.2010.51.32

Polašek, Ozren, Iris Jerončić, Rosanda Mulić, Zorana Klišmanić, Marina Pehlić, Tatijana Zemunik and Ivana Kolčić. "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series." Croatian Medical Journal 51, no. 1 (2010): 32-39. https://doi.org/10.3325/cmj.2010.51.32

Polašek, O., et al. (2010) 'Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series', Croatian Medical Journal, 51(1), pp. 32-39. doi: 10.3325/cmj.2010.51.32

Polašek O, Jerončić I, Mulić R, Klišmanić Z, Pehlić M, Zemunik T, and sur.. Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series. Croatian Medical Journal [Internet]. 2010 February 15 [cited 2024 December 24];51(1):32-39. doi: 10.3325/cmj.2010.51.32

O. Polašek, et al., "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series", Croatian Medical Journal, vol. 51, no. 1, pp. 32-39, February 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:188020. [Accessed: 24 December 2024]

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Metadata
Title (english)Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series
AuthorOzren Polašek
AuthorIris Jerončić
AuthorRosanda Mulić
AuthorZorana Klišmanić
AuthorMarina Pehlić
AuthorTatijana Zemunik
AuthorIvana Kolčić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aim. To investigate whether intra-personal variation in serum uric acid concentration is influenced by genes that were described to be associated with serum uric acid levels in cross-sectional studies. ----- Methods. The study included 92 participants from the isolated community of the Croatian island of Vis. For each participant, two uric acid concentration measurements were available, one from 2002 and one from 2003. Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. ----- Results. Thirteen participants (14%) had uric acid concentration change greater than 130 mumol/L. Greater variability of uric acid concentration was recorded in women (coefficient of variation 49% vs 12% in men). Two SNPs belonging to SLC17A3 gene (rs9393672 and rs942379) yielded significant association with serum uric acid concentration changes in women. These two single-nucleotide polymorphisms (SNP) explained 0.2%-1.3% of variance for 2002 or 2003 uric acid measurement and 1.1%-1.8% of variance for the average value of these two measurements. ----- Conclusions. Repeated measurements offer a possibility to enrich the percent of explained variance and contribute to the understanding of the "missing heritability" concept. Although a number of genes have been shown to affect serum uric acid concentration, SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 51, no. 1, pp. 32-39
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2010.51.32
URN:NBNurn:nbn:hr:105:188020
Publication2010-02-15
Document URLhttp://www.cmj.hr/2010/51/1/20162743.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:31:01