Carotid endarterectomy unexpectedly resulted in optimal blood pressure control

Kirin, Ivan; Kirin, Marijan; Sičaja, Mario; Missoni, Saša; Pehar, Mario; Prka, Željko; Špoljarić, Marko; Božikov, Velimir

Scientific paper - Original scientific paper

Carotid endarterectomy unexpectedly resulted in optimal blood pressure control

Collegium Antropologicum, 33 (2009), 4; 1229-1231. urn:nbn:hr:105:992502

Kirin, Ivan; Kirin, Marijan; Sičaja, Mario; Missoni, Saša; Pehar, Mario; Prka, Željko ; Špoljarić, Marko; Božikov, Velimir

Cite this document

APA 6th Edition

Kirin, I., Kirin, M., Sičaja, M., Missoni, S., Pehar, M., Prka, Ž. ... Božikov, V. (2009). Carotid endarterectomy unexpectedly resulted in optimal blood pressure control . Collegium Antropologicum, 33. (4), 1229-1231. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:992502

MLA 8th Edition

Kirin, Ivan, et al. "Carotid endarterectomy unexpectedly resulted in optimal blood pressure control ." Collegium Antropologicum, vol. 33, no. 4, 2009, pp. 1229-1231. https://urn.nsk.hr/urn:nbn:hr:105:992502

Chicago 17th Edition

Kirin, Ivan, Marijan Kirin, Mario Sičaja, Saša Missoni, Mario Pehar, Željko Prka, Marko Špoljarić and Velimir Božikov. "Carotid endarterectomy unexpectedly resulted in optimal blood pressure control ." Collegium Antropologicum 33, no. 4 (2009): 1229-1231. https://urn.nsk.hr/urn:nbn:hr:105:992502

Harvard

Kirin, I., et al. (2009) 'Carotid endarterectomy unexpectedly resulted in optimal blood pressure control ', Collegium Antropologicum, 33(4), pp. 1229-1231. Available at: https://urn.nsk.hr/urn:nbn:hr:105:992502 (Accessed 22 February 2025)

Vancouver

Kirin I, Kirin M, Sičaja M, Missoni S, Pehar M, Prka Ž, and sur.. Carotid endarterectomy unexpectedly resulted in optimal blood pressure control . Collegium Antropologicum [Internet]. 2009 December [cited 2025 February 22];33(4):1229-1231. Available at: https://urn.nsk.hr/urn:nbn:hr:105:992502

IEEE

I. Kirin, et al., "Carotid endarterectomy unexpectedly resulted in optimal blood pressure control ", Collegium Antropologicum, vol. 33, no. 4, pp. 1229-1231, December 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:992502. [Accessed: 22 February 2025]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:992502

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Title (english)	Carotid endarterectomy unexpectedly resulted in optimal blood pressure control
Title (croatian)	Karotidna endarterektomija neočekivano rezultirala optimalnom kontrolom tlaka
Author	Ivan Kirin
Author	Marijan Kirin
Author	Mario Sičaja
Author	Saša Missoni
Author	Mario Pehar
Author	Željko Prka
Author	Marko Špoljarić
Author	Velimir Božikov
Author's institution	University of Zagreb School of Medicine
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	Resistant hypertension is defined as hypertension that remains above 140/90 mmHg despite the provision of three or more antihypertensive drugs in a rational combination at full doses and including a diuretic. It is associated with adverse clinical outcome and therefore requires aggressive medical treatment. We present a case of 70-year-old woman who was treated for resistant hypertension with a diuretic, ACE-inhibitor, calcium channel blocker, and with centrally acting antihypertensive, moxonodine. Despite of aggressive medical treatment her blood pressure remained above 160/90 mmHg continuously. Large diagnostic workup excluded common causes of secondary hypertension, but revealed significant carotid stenosis present on left internal carotid artery. Carotid endarterectomy was performed in order to improve cerebrovascular prognosis, but unexpectedly resulted in optimal control of her blood pressure. Two months after operation patient was on only one antihypertensive drug, having blood pressure below 130/85 mmHg. We suggest that in selected patients resistant hypertension could be associated with carotid stenosis and carotid sinus baroreceptor dysfunction. For definite conclusions further studies are warranted.
Abstract (croatian)	Rezistentna hipertenzija definirana je kao povišeni krvni tlak iznad 140/90 mmHg unatoč liječenju sa tri ili više antihpertenziva u racionalnoj kombinaciji uz uključeni diuretik. Asocirana je sa nepovoljnom kliničkom prognozom i zahtjeva agresivno liječenje. Prezentiramo slučaj 70-godišnje bolesnice koja je liječena od rezistentne hipertenzije sa diuretikom, ACE-inhibitorom, blokatorom kalcijskih kanala uz centralno djelujući antihipertenziv, moksonidin. Unatoč agresivnom liječenju njezin je tlak bio kontinuirano iznad 160/90 mmHg. Opsežna dijagnostička obrada isključila je uobičajene uzroke sekundarne hipertenzije, ali je otkrila značajnu stenozu lijeve karotide. Učinjena je karotidna endarterektomija sa ciljem da se poboljša cerebrovaskularna prognoza bolesnice, a kao neočekivani postoperativni nalaz javila se normotenzija bolesnice. Na temelju kliničke opservacije sugeriramo da u selekcioniranih bolesnika rezistentna hipertenzija može biti asocirana sa stenozom karotide i disfukcijom karotidnih baroreceptora. Za definitivne zaključke potrebne su kliničke studije.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Collegium Antropologicum
Numbering	vol. 33, no. 4, pp. 1229-1231
p-ISSN	0350-6134
URN:NBN	urn:nbn:hr:105:992502
Publication	2009-12
Document URL	https://hrcak.srce.hr/51504
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2024-03-28 11:37:12