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Scientific paper - Original scientific paper
Morphometry of tumor cells in different grades and types of breast cancer
Collegium Antropologicum, 34 (2010), 1; 99-103. urn:nbn:hr:105:027249
Prvulović, Ivana; Kardum-Skelin, Ika; Susterčić, Dunja; Jakić-Razumović, Jasminka; Manojlović, Spomenka

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Prvulović, I., Kardum Skelin, I., Susterčić, D., Jakić Razumović, J. & Manojlović, S. (2010). Morphometry of tumor cells in different grades and types of breast cancer . Collegium Antropologicum, 34. (1), 99-103. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:027249

Prvulović, Ivana, et al. "Morphometry of tumor cells in different grades and types of breast cancer ." Collegium Antropologicum, vol. 34, no. 1, 2010, pp. 99-103. https://urn.nsk.hr/urn:nbn:hr:105:027249

Prvulović, Ivana, Ika Kardum Skelin, Dunja Susterčić, Jasminka Jakić Razumović and Spomenka Manojlović. "Morphometry of tumor cells in different grades and types of breast cancer ." Collegium Antropologicum 34, no. 1 (2010): 99-103. https://urn.nsk.hr/urn:nbn:hr:105:027249

Prvulović, I., et al. (2010) 'Morphometry of tumor cells in different grades and types of breast cancer ', Collegium Antropologicum, 34(1), pp. 99-103. Available at: https://urn.nsk.hr/urn:nbn:hr:105:027249 (Accessed 13 March 2025)

Prvulović I, Kardum Skelin I, Susterčić D, Jakić Razumović J, Manojlović S. Morphometry of tumor cells in different grades and types of breast cancer . Collegium Antropologicum [Internet]. 2010 March [cited 2025 March 13];34(1):99-103. Available at: https://urn.nsk.hr/urn:nbn:hr:105:027249

I. Prvulović, I. Kardum Skelin, D. Susterčić, J. Jakić Razumović and S. Manojlović, "Morphometry of tumor cells in different grades and types of breast cancer ", Collegium Antropologicum, vol. 34, no. 1, pp. 99-103, March 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:027249. [Accessed: 13 March 2025]

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Metadata
Title (english)Morphometry of tumor cells in different grades and types of breast cancer
Title (croatian)Morfometrija tumorskih stanica kod različitih gradusa i tipova karcinoma dojke
AuthorIvana Prvulović
AuthorIka Kardum-Skelin
AuthorDunja Susterčić
AuthorJasminka Jakić-Razumović
AuthorSpomenka Manojlović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of the study was to compare morphometric characteristics of different types and grades of breast cancer. Morphometric analysis was performed using the SFORM software (Vamstec, Zagreb) on the May-Grünwald-Giemsa stained fine needle aspiration cytology (FNAC) breast tissue specimens. The study included 42 patients diagnosed with breast carcinoma by breast smear FNAC at Merkur University Hospital during the 2001–2005 period. Postoperative tumor histopathology and semi-quantitative tumor grading by the method of Elston and Ellis1 showed invasive ductal carcinoma grade I in 10, invasive ductal carcinoma grade II in 9, invasive ductal carcinoma grade III in 13, and invasive lobular carcinoma in 13 patients, the latter also including a subtype of invasive tubulolobular carcinoma. The following parameters were assessed by use of Statistica 7.1 and c 2-test: tumor area, circumference, maximal radius, minimal radius, convexity, length, width, elongation, nucleus/cytoplasm ratio, and shape factor. Morphometric analysis yielded statistically significant differences among all study groups (p<0.001). Morphometric parameters showed significant individual correlation with tumor type and grade, whereby the area, convexity and circumference were most significant at both nuclear and cellular level.
Abstract (croatian)
Cilj istraživanja bio je usporediti morfometrijske karakteristike karcinoma dojke različitog subtipa i stupnja (gradusa) diferenciranosti. Morfometrijska analiza provedena je na citološkim razmazima punktata dojke obojenim po metodi May-Grünwald-Giemsa (MGG) programom SFORM (Vamstec, Zagreb). Istraživanjem su obuhvaćene 42 bolesnice kod kojih je dijagnoza karcinoma dojke postavljena na uzorcima dobivenim citološkom punkcijom dojke u Kliničkoj bolnici Merkur u razdoblju od 2001. do 2005. godine. Postoperativno je učinjena patohistološka verifikacija te određivanje gradusa tumora semi-kvantitativnom metodom prema Elstonu i Ellisu1. Kod 10 bolesnica radilo se o invazivnom duktalnom karcinomu gradusa I (IDC I), kod 9 bolesnica o invazivnom duktalnom karcinomu gradusa II (IDC II), kod 13 bolesnica o invazivnom duktalnom karcinomu gradusa III (IDC III), a kod 10 bolesnica postavljena je dijagnoza invazivnog lobularnog karcinoma (ILC) u koji je uključen i invazivni tubulo-lobularni karcinom (TLC) kao njegov podtip. Istraživani su slijedeći parametri: površina, opseg, maksimalni radijus, minimalni radijus, konveksitet, dužina, širina, izduženost, omjer jezgra/citoplazma i faktor oblika. Korištena je statistika 7,1, c2-test. Morfometrijska je analiza u ovom istraživanju pokazala statistički značajne razlike, (p<0,001), između svih ispitivanih grupa. Morfometrijski su parametri, primjenjeni pojedinačno, bili značajno povezani sa tipom i gradusom tumora, a najznačajniji su parametri, i za jezgru i za stanicu, bili: površina, konveksitet i opseg.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 34, no. 1, pp. 99-103
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:027249
Publication2010-03
Document URLhttps://hrcak.srce.hr/51249
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:43:16