Role of zinc in chronic gastritis

Scientific paper - Original scientific paper

• Title (croatian): Uloga cinka u kroničnom gastritisu
• Author: Ksenija Marjanović
• Author: Jasna Dovhanj
• Author: Ksenija Kljaić
• Author: Katarina Šakić
• Author: Goran Kondža
• Author: Refmir Tadžić
• Author: Aleksandar Včev
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Oxidative stress occurs in inflammation of gastric mucosa. The role of zinc in modulating oxidative stress has recently been recognized. Zn deficiency results in an increased sensitivity to oxidative stress and have a higher risk of musoca damage in inflammation. The aim of this study was to determine wheather chronic inflammation affects on the concentration of Zn2+ ions in gastric mucosa of patients with chronic gastritis. Forthy-three patients with chronic gastitis were enrolled. Patients were endoscoped. Histology and scoring of gastritis was performed following the guidelines of the updated Sydney system. Endoscopic finding of mucosa were scored according to a Lanza scoring system. The diagnosis of Helicobacter pylori (H. pylori) infection, histopathologic changes, intensity of inflammation and zinc concentration were determined from biopsies of gastric mucosa. The atomic absorption spectrophotometer was used to determine tissue concentrations of zinc. Twenty of 43 patients with chronic gastritis were uninfected by H. pylori. There was no statistically significant difference in tissue concentrations of zinc between H. pylori-positive and H. pylori-negative patients. From those infected patients 53.3% had chronic active gastritis. There was no statistically significant difference in tissue concentrations of zinc between patients with chronic active gastritis and patients with chronic inactive gastritis (p = 0.966). Zn in antrum showed positive correlation with density of H. pylori in antrum (Spearman' rho = 0.481, p = 0.020), negative correlation with density of H. pylori in corpus (Spearman' rho = -0.492, p = 0.017) and with zinc in corpus (Spearman' rho = 0.631, p =0.001). Tissue concentration of zinc was not affected by chronic inflammation of gastric mucosa in patients with chronic gastritis.

Abstract (croatian)

Oksidativni stres se pojavljuje u upali sluznice želuca. Nedavno je uočena uloga cinka u oksidativnom stresu. Deficit cinka dovodi do povećane osjetljivosti na oksidativni stres te povećava rizik oštećenja sluznice tijekom upale. Cilj ovog istraživanja bio je odrediti da li kronična upala utječe na koncentraciju cinkovih iona u sluznici želuca bolesnika sa kroničnim gastritisom. U studiju je bilo uključeno 43 bolesnika sa kroničnim gastritisom kojima je napravljen endoskopski pregled. Histološka analiza i dijagnoza gastritisa napravljena je prema Sydney sistemu. Endoskopski nalaz sluznice bodovan je prema Lanza sistemu. U biopsijama tkiva sluznice želuca određena je dijagnoza Helicobacter pylori infekcije, histopatološka analiza, jačina upale i koncentracija cinka. Dvadeset od 43 bolesnika sa kroničnim gastritisom nije inficirano sa H. pylori. Razlika u koncentraciji cinka u tkivu sluznice između H. pylori pozitivnih i H. pylori negativnih bolesnika nije pronađena. Kod bolesnika sa H. pylori infekcijom 53,3% imalo je kronični aktivni gastritis. Statistički značajna razlika u koncentraciji cinka između bolesnika sa kroničnim aktivnim gastritisom i bolesnika sa kroničnim inaktivnim gastritisom nije pronađena (p=0,966). Pronađena je pozitivna korelacija koncentracije cinka sa H. pylori u antrumu (Spearman’ rho=0,481, p=0,020), negativna sa H. pylori u korpusu (Spearman’ rho=–0,492, p=0,017) i sa cinkom u korpusu (Spearman’ rho=0,631, p=0,001). Kronična upala ne mijenja koncentraciju cinkovih iona u sluznici želuca bolesnika sa kroničnim gastritisom.

• Keywords (english): Biopsy; Chronic Disease; Female; Gastric Mucosa/metabolism; Gastric Mucosa/pathology; Gastritis/metabolism; Gastritis/pathology; Helicobacter Infections/diagnosis; Helicobacter Infections/metabolism; Helicobacter Infections/pathology; Helicobacter pylori/isolation & purification; Humans; Inflammation/pathology; Inflammation/physiopathology; Male; Oxidative Stress/drug effects; Pyloric Antrum/pathology; Zinc/metabolism; Zinc/pharmacology
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 34, no. 2, pp. 599-603
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:149879
• Publication: 2010-06
• Document URL: https://hrcak.srce.hr/56489
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 11:53:19