prikaz prve stranice dokumenta Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms
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Scientific paper - Original scientific paper
Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms
Journal of Affective Disorders, 91 (2006), 1-3; 223-227. https://doi.org/10.1016/j.jad.2006.02.018
Pivac, Nela; Kozarić-Kovačić, Dragica; Mustapić, Maja; Deželjin, Martina; Borovečki, Andreja; Grubišić-Ilić, Mirjana; Muck-Šeler, Dorotea

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Pivac, N., Kozarić Kovačić, D., Mustapić, M., Deželjin, M., Borovečki, A., Grubišić Ilić, M. & Muck Šeler, D. (2006). Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms . Journal of Affective Disorders, 91. (1-3), 223-227. doi: 10.1016/j.jad.2006.02.018

Pivac, Nela, et al. "Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms ." Journal of Affective Disorders, vol. 91, no. 1-3, 2006, pp. 223-227. https://doi.org/10.1016/j.jad.2006.02.018

Pivac, Nela, Dragica Kozarić Kovačić, Maja Mustapić, Martina Deželjin, Andreja Borovečki, Mirjana Grubišić Ilić and Dorotea Muck Šeler. "Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms ." Journal of Affective Disorders 91, no. 1-3 (2006): 223-227. https://doi.org/10.1016/j.jad.2006.02.018

Pivac, N., et al. (2006) 'Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms ', Journal of Affective Disorders, 91(1-3), pp. 223-227. doi: 10.1016/j.jad.2006.02.018

Pivac N, Kozarić Kovačić D, Mustapić M, Deželjin M, Borovečki A, Grubišić Ilić M, and sur.. Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms . Journal of Affective Disorders [Internet]. 2006 July [cited 2024 July 20];91(1-3):223-227. doi: 10.1016/j.jad.2006.02.018

N. Pivac, et al., "Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms ", Journal of Affective Disorders, vol. 91, no. 1-3, pp. 223-227, July 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:472782. [Accessed: 20 July 2024]

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Metadata
Title (english)Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms
AuthorNela Pivac
AuthorDragica Kozarić-Kovačić
AuthorMaja Mustapić
AuthorMartina Deželjin
AuthorAndreja Borovečki
AuthorMirjana Grubišić-Ilić
AuthorDorotea Muck-Šeler
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: Combat-related posttraumatic stress disorder (PTSD) is severe form of PTSD, frequently associated with psychotic symptoms. Platelet serotonin (5-hydroxytryptamine, 5-HT) was used as a peripheral 5-HT marker to identify particular symptoms in PTSD. ----- Methods: Platelet 5-HT was determined fluorimetrically in 67 war veterans with combat related PTSD. 36 combat exposed veterans who did not develop PTSD, 35 veterans with PTSD complicated with psychotic features. PTSD diagnosis of current and chronic PTSD, and clinical symptoms of PTSD and psychoses were assessed according to DSM-IV criteria, using the Clinician Administrated PTSD Scale, and Positive and Negative Syndrome Scale (PANSS). ----- Results: Platelet 5-HT concentration was significantly higher in veterans with psychotic PTSD than in veterans with non-psychotic PTSD, veterans without PTSD, or in control subjects. Platelet 5-HT was significantly positively correlated with the positive symptoms in PANSS subscale, and with the symptoms of delusions within PANSS positive subscale. ----- Limitations: The results were obtained on peripheral 5-HT marker, i.e. platelet 5-HT concentration. ----- Conclusions: Since the delusions are the core psychotic symptoms occurring in our psychotic PTSD patients, the result of the increased platelet 5-HT concentration, associated with delusions, indicate that platelet 5-HT might be used as a trait marker of psychotic symptoms in PTSD, but not as a state marker for PTSD. reserved.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Affective Disorders
Numberingvol. 91, no. 1-3, pp. 223-227
p-ISSN0165-0327
DOIhttps://doi.org/10.1016/j.jad.2006.02.018
URN:NBNurn:nbn:hr:105:472782
Publication2006-07
Document URLhttps://doi.org/10.1016/j.jad.2006.02.018
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 12:02:54