Suvremeni pristup liječenju multiplog mijeloma

master's thesis

• Title (english): Modern approach in treatment of multiple myeloma
• Author: Ivana Latković
• Mentor: Josip Batinić (mentor)
• Committee member: Ana Boban (predsjednik povjerenstva)
• Committee member: Ivana Vuković Brinar (član povjerenstva)
• Committee member: Josip Batinić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2023-09-26, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract

Multipli mijelom je zloćudni tumor koštane srži karakteriziran umnažanjem
abnormalnih klonalnih plazma stanica, s mogućnošću nekontroliranog rasta
uzrokujući destruktivne lezije kostiju, ozljedu bubrega, anemiju i
hiperkalcijemiju. Karakterističan je za osobe starije životne dobi (medijan dobi
kod dijagnoze je 69godina), češća je pojavnost kod muškaraca nego žena, te
bilježi znatno veću učestalost kod crne rase. Nepoznate je etiologije.
Dijagnostika bolesti izuzetno je složena, prvotni pokazatelji su anemija ili
slabokrvnost u krvnoj slici, a elektroforeza proteina u serumu govori u prilog
tzv. M proteina i urinu Bence Jones protein, potom punkcija koštane srži i
neizostavna radiološka dijagnostika. Dugo vremena temelj liječenja MM je
bila citostatska terapija u kombinaciji s drugim lijekovima poput kortikosteroida.
Dostupnost nove generacije lijekova kao što su imunomodulatorna sredstva,
inhibitori proteasoma i monoklonska antitijela, široka primjena transplantacije
matičkih stanica, upotreba napredne dijagnostike koja omogućuje stratifikaciju
rizika i praćenje odgovora na terapiju, te opće poboljšanje zdravstvene skrbi,
multidisciplinaran, te holistički pristup skrbi u velike je poboljšalo ishod
liječenja.

Abstract (english)

Multiple myeloma is a hematologic malignancy characterized by the presence
of abnormal clonal plasma cells in the bone marrow, with the potential for
uncontrolled growth causing destructive bone lesions, kidney injury, anemia,
and hypercalcemia. It occurs usually in older people, it is more common in
men than in women, and it has significantly higher incidence in black race
than in caucasians. Etiology is unknown. Diagnostics of the disease is
extremely complex, the initial indicators are the blood count that can show
anemia, serum protein electrophoresis the so-called M protein and urine
Bence Jones protein, then bone marrow puncture and essential radiological
diagnostics. Cytostatic therapy in combination with other drugs such as
corticosteroids was the mainstream terapy for MM. The availability of a new
generation of drugs such as immunomodulating agents, proteasome inhibitors
and monoclonal antibodies, the widespread use of stem cell transplantation,
the use of advanced diagnostics that enables risk stratification and monitoring
of response to therapy, and the general improvement of health care, a
multidisciplinary and holistic approach to care led to a major improvement of
treatment outcomes.

• Keywords: multipli mijelom; imunomodulatorni lijekovi; inhibitori proteasoma; monoklonska protutijela; transplantacija matičnih stanica; sestrinska skrb
• Keywords (english): multiple myeloma; immunomodulatory drugs; proteasome inhibitors; monoclonal antibodies; stem cell transplantation; nursing care
• Language: croatian
• URN:NBN: urn:nbn:hr:105:234305
• Study programme: Title: Studies in Nursing; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra sestrinstva (magistar/magistra sestrinstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-04-18 09:31:05