Long-term follow-up of complete remission in a patient with advanced hepatocellular carcinoma treated with sorafenib: a case report

Scientific paper - Original scientific paper

• Author: Gordan Adžić
• Author: Juraj Prejac
• Author: Stjepko Pleština
• Author's institution: University of Zagreb; School of Medicine; (Department of Pathophysiology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathophysiology

Abstract (english)

Introduction: Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancer and can be caused by well-known risk factors, including infection with hepatitis B and C viruses, alcohol intake, and metabolic syndrome. The overall prognosis remains poor with a median survival of 1 year for symptomatic advanced-stage cases treated with systemic therapies.

Case description: In July 2020, a 73-year-old male patient presented at our institution with mild abdominal pain and an attack of intense cold. After a radiological workup, the diagnosis of HCC located in the caudate lobe was established. The patient underwent atypical caudate lobe resection, and pathology confirmed the diagnosis of grade 3 HCC. Postoperative MRI showed a new metastasis in the 6th liver segment 1.3 cm in diameter, and a PVT progression which now affected the whole right lobe. The patient was started on sorafenib and demonstrated a complete response which still lasts for more than two years.

Conclusion: We present a rare case of a patient who demonstrated a complete response to sorafenib treatment in advanced HCC with unfavorable prognostic factors.

• Keywords (english): case report; complete response; hepatocellular carcinoma; sorafenib; tyrosine-kinase inhibitor
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Frontiers in Oncology
• Numbering: vol. 13, 1260989
• e-ISSN: 2234-943X
• DOI: https://doi.org/10.3389/fonc.2023.1260989
• URN:NBN: urn:nbn:hr:105:791178
• Publication: 2023-10-10
• Document URL: https://www.frontiersin.org/articles/10.3389/fonc.2023.1260989/full
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-05-10 10:17:30