Sistemni eritematozni lupus u trudnoći

master's thesis

• Title (english): Systemic lupus erythematosus in pregnancy
• Author: Marko Perčić
• Mentor: Snježana Škrablin-Kučić (mentor)
• Committee member: Ratko Matijević (predsjednik povjerenstva)
• Committee member: Dinka Pavičić-Baldani (član povjerenstva)
• Committee member: Snježana Škrablin-Kučić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Sistemni eitematozni lupus (SLE) je autoimuna bolest od koje poglavito obolijevaju žene reprodukcijske dobi. Trudnoća i njen ishod glavna su briga za većinu pacijenata. Rizik za egzacerbacijom bolesti u trudnoći i rizik gubitka ploda te prijevremenog poroda su viši, te je i povećana potreba za sigurnijim liječenjem. S napretkom razumijevanja patogeneze sistemnog eritematoznog lupusa i nužnosti upotrebe imunosupresivne terapije može se postići dobra kontrola bolesti i pacijentima je danas omogućena prilika da začnu i imaju djecu. Savjetovanje o trudnoći i uska suradnja s drugim specijalistima kao što su ginekolozi i reumatolozi ključna je za idealan ishod i majke i djeteta u trudnoći. U ovom radu raspravljene su važne teme poput planiranja trudnoće, kontracepcije, egzacerbacije bolesti u trudnoći i komplikacija, te ishod trudnoće. Isto tako prikazan je i sustavni plan praćenja takve trudnoće kao i pregled lijekova koji se danas koriste, te teme koje su usko povezane sa samom trudnoćom kao što su laktacija i neonatalni lupus.

Abstract (english)

Systemic lupus erythematosus (SLE) is an autoimmune disease that primarily affects women of reproductive age. Pregnancy and its outcome are the main concern for most patients. The risk of exacerbation of the disease during pregnancy and the risk of miscarriage and premature birth are higher, and the increased need for safer treatment. With the advancement of the understanding of the pathogenesis of systemic lupus erythematosus and the necessity of the use of immunosuppressive therapy can be achieved by good control of the disease and the patient is now provided an opportunity to conceive and have children. Advice on pregnancy and close cooperation with other specialists such as gynecologists and rheumatologists is essential for the ideal outcome of both mother and child during pregnancy. In this review, I have also discussed the important issues such as planning pregnancy, contraception, exacerbations of the disease in pregnancy, pregnancy complications and the outcome of pregnancy. Also shown is the systematic monitoring plan such as pregnancy and review of medicines used today, topics that are closely related to the pregnancy, such as lactation and neonatal lupus.

• Keywords: trudnoća; SLE; komplikacije; lijekovi
• Keywords (english): pregnancy; systemic lupus erythematosus; complications; drugs
• Language: croatian
• URN:NBN: urn:nbn:hr:105:933386
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-25 10:49:09