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Scientific paper - Review paper
The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status
Diagnostics, 13 (2023), 18; 2960. https://doi.org/10.3390/diagnostics13182960
Stojić, Josip; Kukla, Michał; Grgurević, Ivica

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Stojić, J., Kukla, M. & Grgurević, I. (2023). The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status. Diagnostics, 13. (18). doi: 10.3390/diagnostics13182960

Stojić, Josip, et al. "The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status." Diagnostics, vol. 13, no. 18, 2023. https://doi.org/10.3390/diagnostics13182960

Stojić, Josip, Michał Kukla and Ivica Grgurević. "The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status." Diagnostics 13, no. 18 (2023). https://doi.org/10.3390/diagnostics13182960

Stojić, J., Kukla, M. and Grgurević, I. (2023) 'The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status', Diagnostics, 13(18). doi: 10.3390/diagnostics13182960

Stojić J, Kukla M, Grgurević I. The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status. Diagnostics [Internet]. 2023 September 15 [cited 2024 December 30];13(18). doi: 10.3390/diagnostics13182960

J. Stojić, M. Kukla and I. Grgurević, "The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status", Diagnostics, vol. 13, no. 18, September 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:495792. [Accessed: 30 December 2024]

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Metadata
Title (english)The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status
AuthorJosip Stojić
AuthorMichał Kukla
AuthorIvica Grgurević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Chronic liver disease (CLD) is a significant global health burden, leading to millions of deaths annually. The gut–liver axis plays a pivotal role in this context, allowing the transport of gut-derived products directly to the liver, as well as biological compounds from the liver to the intestine. The gut microbiota plays a significant role in maintaining the health of the digestive system. A change in gut microbiome composition as seen in dysbiosis is associated with immune dysregulation, altered energy and gut hormone regulation, and increased intestinal permeability, contributing to inflammatory mechanisms and damage to the liver, irrespective of the underlying etiology of CLD. The aim of this review is to present the current knowledge about the composition of the intestinal microbiome in healthy individuals and those with CLD, including the factors that affect this composition, the impact of the altered microbiome on the liver, and the mechanisms by which it occurs. Furthermore, this review analyzes the effects of gut microbiome modulation on the course of CLD, by using pharmacotherapy, nutrition, fecal microbiota transplantation, supplements, and probiotics. This review opens avenues for the translation of knowledge about gut–liver interplay into clinical practice as an additional tool to fight CLD and its complications.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleDiagnostics
Numberingvol. 13, no. 18, 2960
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics13182960
URN:NBNurn:nbn:hr:105:495792
Publication2023-09-15
Document URLhttps://www.mdpi.com/2075-4418/13/18/2960
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-21 08:54:16