Primjena vazoaktivnih lijekova u jedinicama intenzivnog liječenja

master's thesis

• Title (english): Administration of vasoactive drugs in intensive care units
• Author: Dora Kurečić
• Mentor: Dinko Tonković (mentor)
• Committee member: Slobodan Mihaljević (predsjednik povjerenstva)
• Committee member: Marija Bakula (član povjerenstva)
• Committee member: Dinko Tonković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Anaesthesiology, Resuscitation and Intensive Care in Surgical Specialities); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Intensive Care

Abstract

Primjena vazoaktivnih lijekova od velikog je značaja u jedinicama intenzivnog liječenja te se prvenstveno primjenjuju kod
hemodinamski nestabilnih pacijenata s ciljem stabilizacije krvnog tlaka, srčanog minutnog volumena te posljedično odgovarajuće perfuzije tkiva. Vazoaktivne lijekove potrebno je uvesti u terapiju kod pacijenata s neadekvatnim odgovorom na potporu oksigenacijom, ventilacijom i volumnom nadoknadom tekućine. Oni uključuju vazopresore koji imaju izražen učinak vazokonstrikcije, dok lijekovi sa inotropnim učinkom djeluju na srčanu funkciju. Odabir vazoaktivnih lijekova u terapiji ovisi o pacijentovom stanju te etiologiji nastanka hemodinamske nestabilnosti. Neka od stanja koja zahtijevaju potporu vazoaktivnim lijekovima su septički šok, kardiogeni šok, srčano zatajenje, kardiopulmonalna reanimacija, anafilaktički šok itd. Primjena vazoaktivnih lijekova zahtijeva kontinuirano praćenje hemodinamskih funkcija, kao što su krvni tlak, srčani minutni volumen te srčana frekvencija, laboratorijskih vrijednosti i kliničkih znakova kako bi se izbjegle komplikacije i osigurao terapijski učinak. Doziranje lijekova često se titrira prema klinički vidljivom učinku kako bi se izbjegle nuspojave poput ishemije miokarda ili aritmija. Uspješna primjena vazoaktivnih lijekova ovisi o stručnosti medicinskog tima, kontinuiranom praćenju pacijenata i pridržavanju protokola.

Abstract (english)

The administration of vasoactive drugs is of great importance in intensive care units. They are primarily used in hemodynamically unstable patients with the aim of stabilizing blood pressure, cardiac output, and consequently ensuring adequate tissue perfusion. Vasoactive drugs should be introduced into therapy in patients with an inadequate response to oxygenation, ventilation, and fluid resuscitation. These include vasopressors, which have a pronounced vasoconstrictive effect, while drugs with inotropic effects act on cardiac function. The choice of vasoactive drugs in therapy depends on the patient's condition and the etiology of the hemodynamic instability. Some conditions that require support with vasoactive drugs include septic shock, cardiogenic shock, heart failure, cardiopulmonary resuscitation, anaphylactic shock, etc. The administration of vasoactive drugs requires continuous monitoring of hemodynamic functions such as blood pressure, cardiac output, and heart rate, as well as laboratory values and clinical signs to avoid complications and ensure therapeutic effectiveness. Drug dosages are often titrated according to the clinically visible effect to avoid side effects such as myocardial ischemia or arrhythmias. The successful administration of vasoactive drugs relies on the expertise of the medical team, ongoing patient monitoring and adherence to protocols.

• Keywords: vazoaktivni lijekovi; jedinica intenzivnog liječenja; vazopresori; inotropni lijekovi; šok
• Keywords (english): vasoactive drugs; intensive care units; vasopressor; inotrope; shock
• Language: croatian
• URN:NBN: urn:nbn:hr:105:448378
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-21 16:21:52