Uloga srčanih biomarkera i ehokardiografije u procjeni rizika bolesnika s venskom tromboembolijskom bolesti

master's thesis

• Title (english): The role of cardiac biomarkers and echocardiography in risk assessment of patients with venous thromboembolic disease
• Author: Hrvoje Vraneš
• Mentor: Mislav Vrsalović (mentor)
• Committee member: Matias Trbušić (predsjednik povjerenstva)
• Committee member: Boško Skorić (član povjerenstva)
• Committee member: Mislav Vrsalović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

U ovom radu prikazana je uloga srčanih biomarkera i ehokardiografije u procjeni rizika kod bolesnika s venskom tromboembolijskom bolešću. Rad se temelji na analizi duboke venske tromboze, plućne embolije, tromboze jetrenih vena te bolesti cerebralnih vena pružajući pregled liječenja i profilakse venske tromboembolijske bolesti. Srčani biomarkeri, poput moždanog natriuretskog peptida i srčanih troponina pružaju važne informacije o ozljedi miokarda i disfunkciji desne klijetke što su česte komplikacije kod bolesnika s venskom tromboembolijskom bolešću. Uključivanje srčanih biomarkera u modele stratifikacije rizika može pomoći u razlikovanju pacijenata s niskim, srednjim i visokim rizikom te usmjeriti odluke o liječenju poboljšavajući ishode.

Ehokardiografija, kao ključna slikovna metoda u procjeni srčane funkcije kod venske tromboembolijske bolesti, bitna je u identifikaciji težine plućne embolije. Ova neinvazivna tehnika omogućuje vizualizaciju srca i procjenu funkcije desne klijetke te tlačnog opterećenja. Identifikacija povećanja desne klijetke i hipokinezije ehokardiografijom može ukazati na povećani rizik u plućnoj emboliji. Prisutnost disfunkcije desne klijetke na ehokardiografiji povezana je s većim rizikom od kratkotrajne smrtnosti što može utjecati na odabir terapije.

U zaključku, integracija srčanih biomarkera i ehokardiografije ključna je u procjeni rizika kod bolesnika s venskom tromboembolijskom bolešću. Ovi dijagnostički alati pružaju važne uvide u srčanu funkciju, hemodinamski status i prognozu pomažući kliničarima u stratifikaciji pacijenata prema njihovu riziku i optimiziranju terapijskog pristupa s ciljem poboljšanja ishoda.

Abstract (english)

This paper investigates the importance of cardiac biomarkers and echocardiography in risk assessment in patients with venous thromboembolic disease. The paper is based on the analysis of deep vein thrombosis, pulmonary embolism, hepatic vein thrombosis and cerebral vein disease, providing an overview of the treatment and prophylaxis of venous thromboembolic disease. Cardiac biomarkers, such as brain natriuretic peptide and cardiac troponins, provide important information about myocardial injury, and right ventricular dysfunction, which are common complications in patients with venous thromboembolic disease. Incorporating cardiac biomarkers into risk stratification models can help differentiate low-, intermediate-, and high-risk patients and guide treatment decisions, in order to improve outcomes.

Echocardiography, as a key imaging method in assessing cardiac function in venous thromboembolic disease, plays an important role in identifying the severity of pulmonary embolism. This non-invasive technique enables visualization of the heart and assessment of right ventricular function and pressure overload. Identification of right ventricular enlargement and/or hypokinesia by echocardiography may indicate an increased risk in pulmonary embolism. The presence of right ventricular dysfunction on echocardiography is associated with a higher risk of short-term mortality, which may influence the choice of therapy.

In conclusion, the integration of cardiac biomarkers and echocardiography is essential in risk assessment in patients with venous thromboembolic disease. These diagnostic tools provide important insights into cardiac function, hemodynamic status, and prognosis, helping clinicians stratify patients according to their risk and optimize the therapeutic approach to improve outcomes.

• Keywords: biomarkeri; ehokardiografija; kardiologija; procjena rizika; venska tromboembolija
• Keywords (english): biomarkers; cardiology; echocardiography; risk assessment; venous thromboembolism
• Language: croatian
• URN:NBN: urn:nbn:hr:105:805460
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-24 10:08:19