Važnost ranog prepoznavanja bolesnika s uznapredovalom Parkinsonovom bolešću

master's thesis

• Title (english): Importance of early recognition of a patient with advanced Parkinson's disease
• Author: Melita Klaić
• Mentor: Nataša Klepac (mentor)
• Committee member: Damir Petravić (predsjednik povjerenstva)
• Committee member: Mario Habek (član povjerenstva)
• Committee member: Nataša Klepac (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences

Abstract

Brzim porastom oboljelih od Parkinsonove bolesti u svijetu javlja se sve veća potreba za pravodobnim prepoznavanjem i liječenjem uznapredovalih stadija bolesti. Uznapredovala Parkinsonova bolest karakterizirana je pojavom težih motoričkih i nemotoričkih simptoma te znatnim padom kvalitete života bolesnika i njihovih skrbnika. Karakteristični motorički simptomi su diskinezije i motorički simptomi nastali duljom upotrebom konvencionalne farmakološke terapije. Pod nemotoričke simptome uznapredovalih stadija bolesti ubrajaju se halucinacije, kognitivno propadanje i pojava demencije. Pri kliničkoj procjeni progresije bolesti bitno je individualizirati pristup i koristiti dodatne pomoćne alate poput upitnika o motoričkim i nemotoričkim simptomima. Kod pojave simptoma uznapredovale bolesti potrebno je bolesnicima preporučiti napredne metode liječenja. Pod njih spada levodopa/karbidopa intestinalni gel (LCIG), kontinuirana potkožna infuzija apomorfina (CSAI) i duboka moždana stimulaciju (DBS). Edukacijom bolesnika, neurologa i liječnika opće prakse može se postići optimalan pristup bolesnicima s uznapredovalom Parkinsonovom bolešću. Pravovremenim prepoznavanjem simptoma uznapredovalih stadija bolesti otvara se mogućnost liječenja naprednim metodama liječenja koje su prikladne nakon gubitka efektivnosti konvencionalne farmakološke terapije.

Abstract (english)

With the rapid increase in Parkinson's disease cases worldwide, there is a growing need for timely recognition and treatment of advanced stages of the disease. Advanced Parkinson's disease is characterized by the emergence of severe motor and non-motor symptoms and a significant decline in the quality of life for patients and their caregivers. Typical motor
symptoms include dyskinesias and motor symptoms resulting from prolonged use of conventional pharmacological therapy. Non-motor symptoms in advanced stages include hallucinations, cognitive decline, and the onset of dementia. In clinical assessment of disease progression, it is crucial to individualize the approach and use additional supportive tools such as questionnaires on motor and non-motor symptoms. When symptoms of advanced disease appear, advanced treatment methods should be recommended to patients. These include levodopa/carbidopa intestinal gel (LCIG), continuous subcutaneous infusion of apomorphine (CSAI), and deep brain stimulation (DBS). By educating patients, neurologists, and general practitioners, an optimal approach to patients with advanced Parkinson's disease can be achieved. Timely recognition of symptoms in advanced stages of the disease opens up the possibility of treatment with advanced methods, which are suitable after the loss of effectiveness of conventional pharmacological therapy.

• Keywords: kvaliteta života; motorički simptomi; napredne metode liječenja; nemotorički simptomi; Parkinsonova bolest
• Keywords (english): device-aided therapies; motor symptoms; non-motor symptoms; Parkinson's disease; quality of life
• Language: croatian
• URN:NBN: urn:nbn:hr:105:753045
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-25 12:41:57