Trendovi incidencije i mortaliteta od mezotelioma u Hrvatskoj od 2001. do 2021. godine

master's thesis

• Title (english): Incidence and mortality trends of mesothelioma in Croatia from 2001 to 2021
• Author: Drago Baković
• Mentor: Mario Šekerija (mentor)
• Committee member: Nataša Antoljak (predsjednik povjerenstva)
• Committee member: Sanja Musić Milanović (član povjerenstva)
• Committee member: Mario Šekerija (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Medical Statistics, Epidemiology and Medical Informatics); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Epidemiology

Abstract

Cilj: Cilj ovog rada je istražiti trendove incidencije i mortaliteta za mezoteliom u Republici Hrvatskoj u razdoblju od 2001. do 2021. godine i usporediti ih s drugim populacijama.

Metode: Podaci o incidenciji i mortalitetu mezotelioma za period od 2001. do 2021. godine preuzeti su iz baza Hrvatskog zavoda za javno zdravstvo. Dobno-standardizirane stope incidencije i mortaliteta izračunate su metodom direktne standardizacije koristeći Standardno europsko stanovništvo. Trendove incidencije i mortaliteta analizirali smo pomoću Joinpoint programa, verzija 5.1.0. travanj 2024.

Rezultati: Unatoč porastu incidencije i mortaliteta u prvom dijelu promatranog razdoblja, u drugoj polovici 2010-ih dolazi do promjene trendova pri čemu je prvo zabilježen statistički značajan pad incidencije, a posljedično i mortaliteta. Tijekom ukupnog razdoblja istraživanja, ipak je zabilježen porast incidencije mezotelioma, osobito među muškarcima i starijom populacijom. U populaciji starijoj od 75 godina, incidencija je porasla za 210% kod muškaraca i 273% kod žena. U 2021. godini, incidencija mezotelioma u Hrvatskoj bila je niža od prosjeka Europske unije, no zbog kasnije zabrane uporabe azbesta i smanjene dijagnostičke aktivnosti tijekom pandemije COVID-19, ne može se isključiti mogućnost ponovnog rasta incidencije.

Zaključak: Trendovi incidencije mezotelioma u Hrvatskoj slični su onima u zemljama Zapadne Europe s povijesno razvijenom brodogradnjom. Međutim, zbog relativno kasnog uvođenja regulacije uporabe azbesta u profesionalnom okruženju, trendovi incidencije i mortaliteta u Hrvatskoj razlikuju se od onih u ostatku Europske Unije. U narednim desetljećima se očekuje značajniji pad incidencije i mortaliteta u svim zemljama Europske Unije.

Abstract (english)

Objective: This work aims to investigate the incidence and mortality trends for mesothelioma in the Republic of Croatia from 2001 to 2021 and compare them with other populations.

Methods: Data on the incidence and mortality of mesothelioma from 2001 to 2021 were taken from the databases of the Croatian Institute of Public Health. We calculated age-standardized incidence and mortality rates using the direct standardization method using the Standard European Population. Incidence and mortality trends were analyzed using the Joinpoint program, version 5.1.0. April 2024

Results: Despite an increase in incidence and mortality in the first part of the observed period, the second half of the 2010s saw a change in trends, with a statistically significant decline in incidence, followed by a consequent reduction in mortality. However, over the entire research period, there was an overall increase in the incidence of mesothelioma, particularly among men and the elderly population. Among those over 75 years old, the incidence rose by 210% in men and 273% in women. In 2021, the incidence of mesothelioma in Croatia was lower than the European Union average, but due to the later ban on asbestos use and reduced diagnostic activity during the COVID-19 pandemic, the possibility of a future increase in incidence cannot be excluded.

Conclusion: Mesothelioma incidence trends in Croatia are similar to those in Western European countries with a historically developed shipbuilding industry. However, due to the relatively late introduction of the regulation of the use of asbestos in the professional environment, incidence and mortality trends in Croatia differ from those in the rest of the European Union. In the coming decades, a significant decrease in incidence and mortality is expected in all countries of the European Union.

• Keywords: mezoteliom; incidencija; mortalitet; trendovi; Hrvatska
• Keywords (english): mesothelioma; incidence; mortality; trends; Croatia
• Language: croatian
• URN:NBN: urn:nbn:hr:105:974458
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-27 13:51:32