Specifičnosti kontinuiranog mjerenja glukoze u tkivima u stanju šoka

master's thesis

• Title (english): Continuous tissue glucose monitoring in patients in a state of shock
• Author: Anja Grulović
• Mentor: Velimir Altabas (mentor)
• Committee member: Zdravko Babić (predsjednik povjerenstva)
• Committee member: Marija Bakula (član povjerenstva)
• Committee member: Velimir Altabas (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Cirkulacijski šok životno je ugrožavajuće stanje obilježeno smanjenim protokom krvi, kisika i hranidbenih tvari do tkiva i organa te smanjenim otplavljivanjem razgradnih metaboličkih produkata iz perifernih tkiva. Prema etiologiji, cirkulacijski šok dijeli se u kardiogeni, hipovolemijski, distributivni i opstruktivni šok. Tijekom šoka događaju se različiti patofiziološki procesi u organizmu koji katkad rezultiraju poremećajem metabolizma glukoze. Poremećaji metabolizma glukoze poput različitih oblika šećerne bolesti, predijabetesa, stresne hiperglikemije i hipoglikemije mogu povećati rizik od smrtnog ishoda u kritično oboljelih pacijenata. U posljednjih nekoliko godina razvio se uređaj za kontinuirano mjerenje glukoze koji se može ugraditi pacijentima oboljelim od šećerne bolesti. Zbog poboljšanja praćenja varijabilnosti u vrijednosti glukoze kod pacijenata sa šećernom bolešću u stvarnom vremenu, uređaj za kontinuirano mjerenje glukoze predstavlja budućnost praćenja promjena glukoze kod kritično oboljelih pacijenata nakon šoka. Njegova bi primjena omogućila praćenje vrijednosti glukoze svake minute te precizniju primjenu terapije radi očuvanja urednih vrijednosti glukoze. Njegovom primjenom smanjile bi se hipoglikemijske i hiperglikemijske epizode kod pacijenata koje koreliraju s lošijim ishodom. Iako još uvijek ne postoje točno određene smjernice koje definiraju raspon glukoze u tkivima kod ove subpopulacije pacijenata, uređaj za kontinuirano mjerenje glukoze omogućio bi individualizirani pristup održavanja razine glukoze svakog pacijenta.

Abstract (english)

Circulatory shock is a life-threatening condition characterized by reduced blood flow, lowered oxygen and nutrients supply to peripheral tissues and a decreased removal of metabolic products from peripheral tissues. According to its etiology, circulatory shock is classified into cardiogenic, hypovolemic, distributive and obstructive shock. During shock, various pathophysiological processes occur in the body, sometimes resulting in glucose metabolism disorders. Glucose metabolism disorders, such as different forms of diabetes mellitus, prediabetes, stress-induced hyperglycemia and hypoglycemia can increase the risk of mortality in critically ill patients. In recent years, a continuous glucose monitoring device has been developed that can be implanted in patients with diabetes. Due to its improvement in tracking glucose variability in real-time for patients with diabetes, the continuous glucose monitoring device represents the future of monitoring glucose changes in critically ill patients after shock. Its application would allow minute-by-minute monitoring of glucose levels and more precise therapy to maintain normal glucose values. Its use would reduce hypoglycemic and hyperglycemic episodes in patients, which correlate with poorer outcomes. Although there are no precisely defined guidelines defining the range of glucose levels in tissues for this subpopulation of patients, the continuous glucose monitoring device would enable an individualized approach to maintaining each patient's glucose levels.

• Keywords: cirkulacijski šok; stresna hiperglikemija; hipoglikemija; smrtni ishod; uređaj za kontinuirano praćenje glukoze
• Keywords (english): circulatory shock; stress hyperglycemia; hypoglycemia; mortality; continuous glucose monitoring device
• Language: croatian
• URN:NBN: urn:nbn:hr:105:929006
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-29 09:48:23