Title Virusne spolno prenosive bolesti u trudnoći Title (english) Viral sexually transmitted disease in pregnancy Author Antea Džapo Mentor Suzana Ljubojević Hadžavdić (mentor)Committee member Mihael Skerlev (predsjednik povjerenstva)Committee member Krešimir Kostović (član povjerenstva)Committee member Suzana Ljubojević Hadžavdić (član povjerenstva)Granter University of Zagreb Defense date and country 2014-07-15, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Spolno prenosive infekcije uzrokovane su različitim uzročnicima i prenose se spolnim kontaktom. Najznačajniji uzročnici virusnih spolno prenosivih bolesti su humani papiloma virus, humani virus imunodeficijencije, hepatitis virusi, virus herpes simplex, molluscum contagiosum virus te citomegalovirus. Tijekom trudnoće mijenja se učinkovitost majčina imunog sustava i tada postoji povećana sklonost infekcijama. Virusne infekcije kod majke imaju utjecaj na majčino i na djetetovo zdravlje. Vertikalni prijenos može se dogoditi u trudnoći, za vrijeme poroda i u postpartalnom periodu. Herpes simplex virus povezuje se sa spontanim pobačajem, intrauterino zaostalim rastom, kongenitalnim malformacijama i novorođenačkim herpetičkim infekcijama. Prijenos humanog papiloma virusa na dijete tijekom trudnoće može rezultirati pojavom laringealne papilomatoze. Infekcija molluscum contagiosum virusom majke za vrijeme poroda povezuje se s kožnom diseminiranom infekcijom djeteta. Vertikalni prijenos virusa humane imunodeficijencije karakterizira specifična HIV embriopatija, prijevremeni porod, spontani pobačaj i rođenje djeteta premale tjelesne težine. Prijenos s majke na dijete najčešći je način inficiranja djece HIV-om. Citomegalovirus je najčešći uzročnik intrauterine infekcije fetusa, a karakterizira ga intrauterino zaostali rast, hepatosplenomegalija, žutica, limfadenopatija, gubitak sluha, korioretinitis, mikrocefalija s intrakranijalnim kalcifikacijama, retinitis, trombocitopenija i pancitopenija. Akutna hepatitis B infekcija nema teratogeno djelovanje, no zabilježeni su slučajevi novorođenčeta s niskom tjelesnom težinom i prijevremeni porod. Rizik vertikalnog prijenosa virusa hepatitisa B ovisi o gestacijskoj dobi te trajanju infekcije i iznosi 10 – 90 %, dok kod virusa hepatitisa C iznosi < 5 %. Trudnice bi se trebale testirati na spolno prenosive infekcije, provoditi odgovarajuće preventivne mjere kako bi se reducirao perinatalni morbiditet i mortalitet od spolno prenosivih bolesti.
Abstract (english) Sexually transmitted infections are caused by different pathogens during sexual contact. The most important viral sexually transmitted diseases are human papillomavirus, human immunodeficiency virus, hepatitis virus, herpes simplex virus, molluscum contagiosum virus, and cytomegalovirus. During pregnancy the mother's immune system is changing and there is an increased susceptibility to infections. Maternal viral infections have an impact on both mother and child's health. Vertical transmission can occur during pregnancy, childbirth and postpartum period. Herpes simplex virus is associated with spontaneous abortion, intrauterine growth restriction, congenital malformations and neonatal herpetic infections. Transmission of human papilloma virus to fetus during pregnancy can result with appearance of laryngeal papillomatosis. Mother's molluscum contagiosum infection during delivery could be associated with child's skin disseminated infection. Vertical transmission of human immunodeficiency virus is characterized by a specific HIV embriopathy, premature birth, miscarriage and low body weight at birth. Transmission from mother to child is the most common way of infecting children with HIV. Cytomegalovirus is the most common cause of intrauterine infection and is characterized by intrauterine growth restriction, hepatosplenomegaly, jaundice, lymphadenopathy, hearing loss, chorioretinitis, microcephaly with intracranial calcifications, retinitis, thrombocytopenia, and pancytopenia. Acute hepatitis B infection, but no teratogenic effects, have been reported in the cases of newborn with low birth weight and preterm birth. The risk of vertical transmission of hepatitis B virus depends on gestational age and duration of infection is 10 – 90 % while the hepatitis C virus is < 5 %. All pregnant women should be tested for sexually transmitted infections, use adequate prevention measures in order to prevent morbidity and mortality caused by sexually transmitted diseases.
Keywords
virusne spolno prenosive bolesti
trudnoća
novorođenče
Keywords (english)
viral sexually transmitted diseases
pregnancy
infant
Language croatian URN:NBN urn:nbn:hr:105:814309 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2015-10-07 08:01:42
