prikaz prve stranice dokumenta Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients
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Scientific paper - Original scientific paper
Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients
Life, 13 (2023), 8; 1699. https://doi.org/10.3390/life13081699
Lucijanić, Marko; Tješić-Drinković, Ida; Piskač Živković, Nevenka; Paštrović, Frane; Rob, Zrinka; Bačevac, Mersiha; Sedinić Lacko, Martina; Džambas, Eleonora; Medić, Barbara; Vukoja, Ivan; Bušić, Iva; Grgurević, Ivica; Lukšić, Ivica; Baršić, Bruno

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Lucijanić, M., Tješić Drinković, I., Piskač Živković, N., Paštrović, F., Rob, Z., Bačevac, M. ... Baršić, B. (2023). Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients. Life, 13. (8). doi: 10.3390/life13081699

Lucijanić, Marko, et al. "Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients." Life, vol. 13, no. 8, 2023. https://doi.org/10.3390/life13081699

Lucijanić, Marko, Ida Tješić Drinković, Nevenka Piskač Živković, Frane Paštrović, Zrinka Rob, Mersiha Bačevac, Martina Sedinić Lacko, et al. "Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients." Life 13, no. 8 (2023). https://doi.org/10.3390/life13081699

Lucijanić, M., et al. (2023) 'Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients', Life, 13(8). doi: 10.3390/life13081699

Lucijanić M, Tješić Drinković I, Piskač Živković N, Paštrović F, Rob Z, Bačevac M, and sur.. Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients. Life [Internet]. 2023 August 07 [cited 2024 November 11];13(8). doi: 10.3390/life13081699

M. Lucijanić, et al., "Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients", Life, vol. 13, no. 8, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:675492. [Accessed: 11 November 2024]

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Metadata
Title (english)Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients
AuthorMarko Lucijanić
AuthorIda Tješić-Drinković
AuthorNevenka Piskač Živković
AuthorFrane Paštrović
AuthorZrinka Rob
AuthorMersiha Bačevac
AuthorMartina Sedinić Lacko
AuthorEleonora Džambas
AuthorBarbara Medić
AuthorIvan Vukoja
AuthorIva Bušić
AuthorIvica Grgurević
AuthorIvica Lukšić
AuthorBruno Baršić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Thromboprophylaxis is a mainstay of treatment of hospitalized COVID-19 patients, due to the high occurrence of thrombotic events. This increases the risk of bleeding. However, data on bleeding events and associated risk factors are scarce. Thus, we aimed to investigate the incidence, predictors and clinical outcomes associated with major bleeding in hospitalized COVID-19 patients. We retrospectively evaluated a cohort of 4014 consecutively hospitalized COVID-19 patients treated in a tertiary-level institution in the period 3/2020–3/2021. Bleeding of any kind was documented in 322 (8%) and major bleeding in 129 (3.2%) patients. A total of 129 (40.1%) bleeding events were present at the time of hospital admission, and 193 (59.9%) occurred during hospitalization. In the multivariate logistic regression analysis, intensive-care-unit treatment (adjusted odds ratio (aOR) 6.55; p < 0.001), atrial fibrillation (aOR 2.55; p = 0.029), higher white-blood-cell count (WBC) (aOR 1.03; p = 0.021), lower hemoglobin (aOR 0.97; p = 0.002) and history of bleeding (aOR 17.39; p < 0.001) were recognized as mutually independent predictors of major bleeding. Major bleeding was significantly associated with increased in-hospital mortality compared to non-major-bleeding patients (59.7% vs. 34.8%, p < 0.001), especially if occurring during hospitalization. Median time from major bleeding to death was 5 days. Bleeding events are frequent in hospitalized COVID-19 patients, with a significant proportion of patients presenting at the time of hospital admission, and others almost universally exposed to anticoagulant and corticosteroid therapies. Major bleeding is associated with high mortality, especially if occurring during hospitalization. The recognition of patients at risk and implementation of timely interventions are of high clinical importance.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLife
Numberingvol. 13, no. 8, 1699
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life13081699
URN:NBNurn:nbn:hr:105:675492
Publication2023-08-07
Document URLhttps://www.mdpi.com/2075-1729/13/8/1699
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-08-19 08:53:36