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Scientific paper - Original scientific paper
HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers
Pathogens, 12 (2023), 8; 1013. https://doi.org/10.3390/pathogens12081013
Lulić, Lucija; Jakovčević, Antonia; Kovačić, Iva; Manojlović, Luka; Dediol, Emil; Skelin, Josipa; Tomaić, Vjekoslav

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Lulić, L., Jakovčević, A., Kovačić, I., Manojlović, L., Dediol, E., Skelin, J. & Tomaić, V. (2023). HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers. Pathogens, 12. (8). doi: 10.3390/pathogens12081013

Lulić, Lucija, et al. "HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers." Pathogens, vol. 12, no. 8, 2023. https://doi.org/10.3390/pathogens12081013

Lulić, Lucija, Antonia Jakovčević, Iva Kovačić, Luka Manojlović, Emil Dediol, Josipa Skelin and Vjekoslav Tomaić. "HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers." Pathogens 12, no. 8 (2023). https://doi.org/10.3390/pathogens12081013

Lulić, L., et al. (2023) 'HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers', Pathogens, 12(8). doi: 10.3390/pathogens12081013

Lulić L, Jakovčević A, Kovačić I, Manojlović L, Dediol E, Skelin J, and sur.. HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers. Pathogens [Internet]. 2023 August 03 [cited 2024 November 16];12(8). doi: 10.3390/pathogens12081013

L. Lulić, et al., "HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers", Pathogens, vol. 12, no. 8, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:949477. [Accessed: 16 November 2024]

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Metadata
Title (english)HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers
AuthorLucija Lulić
AuthorAntonia Jakovčević
AuthorIva Kovačić
AuthorLuka Manojlović
AuthorEmil Dediol
AuthorJosipa Skelin
AuthorVjekoslav Tomaić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Infection with human papillomaviruses (HPVs), in particular with HPV type 16, is now considered to be a key risk factor for the development of a subset of oropharyngeal squamous cell carcinomas (OPSCC) that show different epidemiological, clinical, and prognostic characteristics from HPV-negative (HPV−) OPSCCs. So far, extensive research efforts aiming to distinguish these two distinct entities have not identified specific biomarkers, nor led to different therapies. Previous research has shown that HPV16 E6 oncoprotein binds NHERF2, inducing its proteasomal degradation, and consequently increasing cell proliferation; we therefore aimed to investigate how this might be reflected in human histological samples. We analyzed NHERF2 expression patterns in HPV16-positive (HPV16+) and HPV− OPSCC samples, to investigate any potential differences in NHERF2 pattern. Interestingly, we observed a statistically significant decrease in NHERF2 levels in HPV16+ and poorly differentiated HPV− OPSCCs, compared with healthy tissue. Furthermore, we observed a significant reduction in the percentage of NHERF2 immunoreactive cancer cells in HPV16+ tumors, compared with well and moderately differentiated HPV− OPSCCs, suggesting the importance of 16E6’s targeting of NHERF2 in HPV-driven oncogenesis in the head and neck area.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePathogens
Numberingvol. 12, no. 8, 1013
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens12081013
URN:NBNurn:nbn:hr:105:949477
Publication2023-08-03
Document URLhttps://www.mdpi.com/2076-0817/12/8/1013
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-08-20 10:19:14