Acute Liver Failure Caused by Secondary Hemophagocytic Lymphohistiocytosis After COVID-19 Vaccination – Case Report and Literature Review

Scientific paper - Case study

• Author: Hrvoje Premec
• Author: Matea Živko
• Author: Maja Mijić
• Author: Biljana Jelić-Puškarić
• Author: Miloš Lalovac
• Author: Tajana Filipec Kanižaj
• Author: Nikola Sobočan
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (english)

Hemophagocytic lymphohistiocytosis (HLH) is a congenital or acquired hyperinflammatory syndrome, in some cases accompanied by acute liver failure. We present a case report of acute liver failure associated with HLH after COVID-19 vaccination and bring a literature review of the connection between HLH and COVID-19 vaccination. HLH has significant mortality rate, and liver transplantation is not a therapeutic option. Therefore, early recognition and timely conservative treatment are corner stones in reducing HLH-related morbidity and mortality.

• Keywords (english): COVID-19 vaccine; acute liver failure; hemophagocytic lymphohistiocytosis; multisystem inflammatory syndrome
• Language: english
• Publication type: Scientific paper - Case study
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: International Medical Case Reports Journal
• Numbering: vol. 16, pp. 449-455
• e-ISSN: 1179-142X
• DOI: https://doi.org/10.2147/IMCRJ.S417347
• URN:NBN: urn:nbn:hr:105:046679
• Publication: 2023-08-07
• Document URL: https://www.dovepress.com/acute-liver-failure-caused-by-secondary-hemophagocytic-lymphohistiocyt-peer-reviewed-fulltext-article-IMCRJ
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-08-26 08:08:36