Analiza ishoda liječenja kronične ugrožavajuće ishemije ekstremiteta

master's thesis

• Title (english): Treatment outcomes in patients with chronic limb-threatening ischemia
• Author: Ines Prskalo
• Mentor: Majda Vrkić Kirhmajer (mentor)
• Committee member: Kristina Marić Bešić (predsjednik povjerenstva)
• Committee member: Boško Skorić (član povjerenstva)
• Committee member: Majda Vrkić Kirhmajer (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2024-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract

Kronična ugrožavajuća ishemija ekstremiteta (CLTI) kao zadnji stadij periferne arterijske bolesti predstavlja ozbiljan zdravstveni problem s visokom stopom mortaliteta, morbiditeta i amputacija. Ovaj diplomski rad analizira jednogodišnje kliničke ishode bolesnika s CLTI liječenih različitim metodama revaskularizacije u Kliničkom bolničkom centru Zagreb. Istraživanje je retrospektivno, a uključeno je 149 bolesnika hospitaliziranih u razdoblju od svibnja 2021. do lipnja 2022. godine. Glavni cilj rada bio je ispitati preživljenje bez amputacije (AFS) i ukupni jednogodišnji mortalitet među bolesnicima s CLTI. Također su analizirani rani hospitalni ishodi, uključujući mortalitet i stopu amputacija te trajanje hospitalizacije u odnosu na primijenjene metode liječenja (endovaskularna, kirurška, hibridna ili konzervativna). Rezultati su pokazali da je endovaskularna revaskularizacija bila najčešće korištena metoda (62,4%), dok je kirurška revaskularizacija primijenjena u 17,4% slučajeva. Unatoč razlici u trajanju hospitalizacije, nije pronađena značajna razlika u stopama mortaliteta ili amputacija među različitim metodama liječenja. Jednogodišnje preživljenje bez amputacije zabilježeno je u 63,8% bolesnika, dok su mortalitet i velike amputacije zabilježeni kod 17,4% i 18,1% bolesnika. Rezultati ovog istraživanja ukazuju na važnost individualiziranog pristupa liječenju bolesnika s CLTI, s naglaskom na pažljivoj procjeni kliničkih karakteristika bolesnika uz multidisciplinarni odabir metode revaskularizacije.

Abstract (english)

Chronic limb-threatening ischemia (CLTI), as the final stage of peripheral artery disease, represents a serious health problem with high rates of mortality, morbidity, and amputations. This thesis analyses the one-year clinical outcomes of patients with CLTI treated with various revascularization methods at the Clinical Hospital Centre Zagreb. The study is retrospective and includes 149 patients hospitalized between May 2021 and June 2022. The main objective of the study was to examine amputation-free survival (AFS) and overall one-year mortality among patients with CLTI. Early hospital outcomes, including mortality and amputation rates, as well as the duration of hospitalization in relation to the applied treatment methods (endovascular, surgical, hybrid, or conservative), were also analysed. The results showed that endovascular revascularization was the most commonly used method (62.4%), while surgical revascularization was applied in 17.4% of cases. Despite differences in hospitalization duration, no significant difference was found in mortality or amputation rates among the different treatment methods. One-year amputation-free survival was recorded in 63.8% of patients, while mortality and major amputations were observed in 17.4% and 18.1% of patients, respectively. The results of this study highlight the importance of an individualized approach to the treatment of CLTI patients, emphasizing the assessment of patients' clinical characteristics and careful, multidisciplinary selection of the revascularization method.

• Keywords: kronična ugrožavajuća ishemija ekstremiteta; revaskularizacija; mortalitet; preživljenje bez amputacije; amputacije
• Keywords (english): chronic limb-threatening ischemia; revascularization; mortality; amputation free survival; amputations
• Language: croatian
• URN:NBN: urn:nbn:hr:105:070844
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-04 11:41:18