Calcium-Sensing Receptor Expression in Breast Cancer

Scientific paper - Original scientific paper

• Author: Iva Bušić-Pavlek
• Author: Ivo Dumić-Čule
• Author: Lucija Kovačević
• Author: Milan Milošević
• Author: Petra Delimar
• Author: Lea Korša
• Author: Zlatko Marušić
• Author: Maja Prutki
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Author's institution: University of Zagreb; School of Medicine; (Department of Radiology)
• Author's institution: University of Zagreb; School of Medicine; (Department of Environmental and Occupational Health)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Occupational and Sports Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (english)

The calcium-sensing receptor (CaSR) plays a crucial role in maintaining the balance of calcium in the body. Altered signaling through the CaSR has been linked to the development of various tumors, such as colorectal and breast tumors. This retrospective study enrolled 79 patients who underwent surgical removal of invasive breast carcinoma of no special type (NST) to explore the expression of the CaSR in breast cancer. The patients were categorized based on age, tumor size, hormone receptor status, HER2 status, Ki-67 proliferation index, tumor grade, and TNM staging. Immunohistochemistry was conducted on core needle biopsy samples to assess CaSR expression. The results revealed a positive correlation between CaSR expression and tumor size, regardless of the tumor surrogate subtype (p = 0.001). The expression of ER exhibited a negative correlation with CaSR expression (p = 0.033). In contrast, a positive correlation was observed between CaSR expression and the presence of HER2 receptors (p = 0.002). Increased CaSR expression was significantly associated with lymph node involvement and the presence of distant metastasis (p = 0.001 and p = 0.038, respectively). CaSR values were significantly higher in the patients with increased Ki-67 (p = 0.042). Collectively, higher CaSR expression in breast cancer could suggest a poor prognosis and treatment outcome regardless of the breast cancer subtype.

• Keywords (english): Biomarkers, Tumor / metabolism; Breast Neoplasms / metabolism; Female; Humans; Ki-67 Antigen / genetics; Ki-67 Antigen / metabolism; Receptor, ErbB-2 / metabolism; Receptors, Calcium-Sensing / genetics; Receptors, Progesterone / metabolism; Retrospective Studies
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: International Journal of Molecular Sciences
• Numbering: vol. 24, no. 14, 11678
• e-ISSN: 1422-0067
• DOI: https://doi.org/10.3390/ijms241411678
• URN:NBN: urn:nbn:hr:105:873075
• Publication: 2023-07-20
• Project: Number: IP-2019-04-3684; Title (croatian): Biomedicinsko oslikavanje karcinoma dojke; Title (english): Biomedical imaging of breast carcinoma; Acronym: BOBCAt; Leader: Maja Prutki; Jurisdiction: Croatia; Funding stream: Research Projects
• Document URL: https://www.mdpi.com/1422-0067/24/14/11678
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-09-04 11:46:08