prikaz prve stranice dokumenta Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia
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Scientific paper - Original scientific paper
Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia
Genes, 14 (2023), 7; 1358. https://doi.org/10.3390/genes14071358
Šagud, Marina; Tudor, Lucija; Nedić Erjavec, Gordana; Nikolac Perkovič, Matea; Uzun, Suzana; Mimica, Ninoslav; Madžarac, Zoran; Živkovic, Maja; Kozumplik, Oliver; Konjevod, Marcela; Švob Štrac, Dubravka; Pivac, Nela

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Šagud, M., Tudor, L., Nedić Erjavec, G., Nikolac Perkovič, M., Uzun, S., Mimica, N. ... Pivac, N. (2023). Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia. Genes, 14. (7). doi: 10.3390/genes14071358

Šagud, Marina, et al. "Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia." Genes, vol. 14, no. 7, 2023. https://doi.org/10.3390/genes14071358

Šagud, Marina, Lucija Tudor, Gordana Nedić Erjavec, Matea Nikolac Perkovič, Suzana Uzun, Ninoslav Mimica, Zoran Madžarac, et al. "Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia." Genes 14, no. 7 (2023). https://doi.org/10.3390/genes14071358

Šagud, M., et al. (2023) 'Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia', Genes, 14(7). doi: 10.3390/genes14071358

Šagud M, Tudor L, Nedić Erjavec G, Nikolac Perkovič M, Uzun S, Mimica N, and sur.. Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia. Genes [Internet]. 2023 June 27 [cited 2024 December 20];14(7). doi: 10.3390/genes14071358

M. Šagud, et al., "Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia", Genes, vol. 14, no. 7, June 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:567260. [Accessed: 20 December 2024]

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Title (english)Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia
AuthorMarina Šagud
AuthorLucija Tudor
AuthorGordana Nedić Erjavec
AuthorMatea Nikolac Perkovič
AuthorSuzana Uzun
AuthorNinoslav Mimica
AuthorZoran Madžarac
AuthorMaja Živkovic
AuthorOliver Kozumplik
AuthorMarcela Konjevod
AuthorDubravka Švob Štrac
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Catechol-O-methyl transferase (COMT) gene variants are involved in different neuropsychiatric disorders and cognitive impairments, associated with altered dopamine function. This study investigated the genotypic and haplotypic association of COMT rs4680 and rs4618 polymorphisms with the severity of cognitive and other clinical symptoms in 544 male and 385 female subjects with schizophrenia. COMT rs4818 G carriers were more frequent in male patients with mild abstract thinking difficulties, compared to CC homozygotes or C allele carriers. Male carriers of COMT rs4680 A allele had worse abstract thinking (N5) scores than GG carriers, whereas AA homozygotes were more frequent in male subjects with lower scores on the intensity of the somatic concern (G1) item, compared to G carriers. Male carriers of COMT rs4818–rs4680 GA haplotype had the highest scores on the G1 item (somatic concern), whereas GG haplotype carriers had the lowest scores on G2 (anxiety) and G6 (depression) items. COMT GG haplotype was less frequent in female patients with severe disturbance of volition (G13 item) compared to the group with mild symptoms, while CG haplotype was more frequent in female patients with severe then mild symptoms. These findings suggest the sex-specific genotypic and haplotypic association of COMT variants with a severity of cognitive and other clinical symptoms of schizophrenia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleGenes
Numberingvol. 14, no. 7, 1358
e-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes14071358
URN:NBNurn:nbn:hr:105:567260
Publication2023-06-27
Document URLhttps://www.mdpi.com/2073-4425/14/7/1358
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-09-05 07:29:44