Imuni i neimuni fetalni hidrops

master's thesis

• Title (english): Immune and non-immune fetal hydrops
• Author: Romana Jurić
• Mentor: Ivanka Bekavac Vlatković (mentor)
• Committee member: Vladimir Blagaić (predsjednik povjerenstva)
• Committee member: Željko Duić (član povjerenstva)
• Committee member: Ivanka Bekavac Vlatković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2024-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Fetalni hidrops označava nakupljanje tekućine u najmanje dva različita fetalna prostora, kao što su trbušna šupljina, pluća, srce ili koža. Ovo stanje može biti uzrokovano različitim etiološkim čimbenicima, imunološke ili neimunološke prirode.

Imuni fetalni hidrops nastaje kao posljedica hemolitičke bolesti fetusa, koju uzrokuju majčina protutijela koja napadaju fetalne eritrocite. Najčešći uzrok ovog oblika hidropsa je RhD aloimunizacija, pri kojoj majčino tijelo proizvodi protutijela protiv... More RhD pozitivnih fetalnih eritrocita. Iako je primjena anti-D imunoglobulina znatno smanjila učestalost ovog poremećaja, i dalje postoji mogućnost imunizacije zbog prisutnosti drugih Rh antigena ili antigena iz drugih krvnih grupa. U slučaju teške anemije uzrokovane hemolitičkom bolešću, intrauterine transfuzije mogu biti potrebne za stabiliziranje stanja.

Neimuni fetalni hidrops čini više od 90% svih slučajeva fetalnog hidropsa. Ovaj oblik hidropsa može biti uzrokovan različitim čimbenicima, uključujući poremećaje strukture i funkcije srca, kromosomske poremećaje, malformacije ili infektivne bolesti. Dijagnoza se postavlja ultrazvukom, prepoznavanjem znakova kao što su ascites, pleuralni izljev, perikardijalni izljev ili edem kože. Rano prepoznavanje i praćenje ovog stanja ključni su za pravilan tretman i smanjenje mogućih komplikacija. Važno je učiniti sveobuhvatnu obradu, uključujući pretrage za otkrivanje uzroka i planiranje odgovarajućeg liječenja. Less

Abstract (english)

Fetal hydrops is characterized by the accumulation of fluid in at least two different fetal compartments, such as the abdominal cavity, lungs, heart, or skin. This condition can be caused by various factors, either immunological or non-immunological.

Immune fetal hydrops results from hemolytic disease of the fetus, caused by maternal antibodies attacking fetal red blood cells. The most common cause of this type of hydrops is RhD alloimmunization, where the mother’s body produces antibodies... More against RhD-positive fetal red blood cells. Although the use of anti-D immunoglobulin has significantly reduced the frequency of this disorder, there is still a risk of sensitization due to the presence of other Rh antigens or antigens from other blood group systems. In cases of severe anemia caused by hemolytic disease, intrauterine transfusions may be necessary to stabilize the condition.

Non-immune fetal hydrops accounts for more than 90% of all cases of fetal hydrops. This form of hydrops can be caused by a range of factors, including cardiac structural and functional abnormalities, chromosomal disorders, malformations, or infections. Diagnosis is made through ultrasound by identifying signs such as ascites, pleural effusion, pericardial effusion, or skin edema. Early detection and monitoring of this condition are crucial for effective treatment and reducing potential complications. A comprehensive approach is essential, including tests to identify the underlying cause and plan appropriate management. Less

• Keywords: imuni fetalni hidrops; aloimunizacija; neimuni fetalni hidrops; intrauterina transfuzija krvi; porod
• Keywords (english): immune fetal hydrops; alloimmunization; non-immune fetal hydrops; intrauterine blood transfusion; delivery
• Language: croatian
• URN:NBN: urn:nbn:hr:105:349683
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-10 21:02:27