Interakcija između cerebrovaskularne bolesti i Alzheimerove bolesti

master's thesis

• Title (english): Interaction between cerebrovascular disease and Alzheimer's disease
• Author: Anamaria Vukoja
• Mentor: Nataša Klepac (mentor)
• Committee member: Damir Petravić (predsjednik povjerenstva)
• Committee member: Mario Habek (član povjerenstva)
• Committee member: Nataša Klepac (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Neurology); Zagreb
• Defense date and country: 2024-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Neurology

Abstract

Interakcija između cerebrovaskularnih bolesti i Alzheimerove bolesti predstavlja složen odnos u
kojem vaskularna oštećenja mozga mogu ubrzati i pogoršati simptome Alzheimerove bolesti.
Cerebrovaskularne bolesti smanjuju dotok krvi u mozak, što može dovesti do oštećenja
moždanog tkiva i dodatno narušiti kognitivne funkcije. Ovo oštećenje pojačava učinke
Alzheimerove bolesti, koja je već obilježena nakupljanjem amiloidnih plakova i tau proteina u
mozgu. Kombinacija ovih patoloških procesa rezultira bržim napredovanjem demencije i težim
kliničkim ishodima za pacijente. Vaskularni čimbenici poput hipertenzije i dijabetesa dodatno
doprinose razvoju obje bolesti, što naglašava važnost njihove prevencije i liječenja. Kontrola
krvnog tlaka i razine šećera u krvi može pomoći u usporavanju napredovanja Alzheimerove
bolesti, dok liječenje cerebrovaskularnih bolesti može poboljšati kognitivne funkcije kod
oboljelih. Terapije usmjerene na poboljšanje cerebralne perfuzije također imaju pozitivan učinak
na kogniciju. Ipak, mnogi pacijenti s kombinacijom ovih bolesti suočavaju se s lošom
prognozom i većom stopom invaliditeta. Stoga je rano prepoznavanje i liječenje
cerebrovaskularnih čimbenika rizika ključno za poboljšanje ishoda kod pacijenata s
Alzheimerovom bolešću. Konačno, integrirani pristup koji obuhvaća prevenciju i liječenje obje
bolesti nudi najbolje izglede za očuvanje kognitivnih funkcija i kvalitete života.

Abstract (english)

The interaction between cerebrovascular diseases and Alzheimer’s disease represents a complex relationship where vascular damage in the brain can accelerate and worsen the symptoms of Alzheimer’s disease. Cerebrovascular diseases reduce blood flow to the brain, which can lead to brain tissue damage and further impair cognitive functions. This damage exacerbates the effects of Alzheimer’s disease, which is already characterized by the accumulation of amyloid plaques and tau proteins in the brain. The combination of these pathological processes results in faster dementia progression and more severe clinical outcomes for patients. Vascular factors such as hypertension and diabetes also contribute to the development of both diseases, highlighting the importance of their prevention and treatment. Controlling blood pressure and blood sugar levels can help slow the progression of Alzheimer’s disease, while treating cerebrovascular diseases can improve cognitive functions in affected individuals. Therapies aimed at improving cerebral perfusion also have a positive impact on cognition. However, many patients with a combination of these diseases face a poor prognosis and higher rates of disability. Therefore, early recognition and treatment of cerebrovascular risk factors are crucial for improving outcomes in patients with Alzheimer’s disease. Finally, an integrated approach that includes the prevention and treatment of both diseases offers the best prospects for preserving cognitive functions and quality of life.

• Keywords: Cerebrovaskularna bolest; Alzheimerova bolest; kognitivna funkcija; amiloidni plak
• Keywords (english): Cerebrovascular disease; Alzheimer's disease; cognitive function; amiloid plaque
• Language: croatian
• URN:NBN: urn:nbn:hr:105:254034
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-11 11:51:10