Primary Cutaneous Lymphoma

master's thesis

• Title (croatian): Primarni limfomi kože
• Author: Yotam Malek
• Mentor: Romana Čeović (mentor)
• Committee member: Romana Čeović (predsjednik povjerenstva)
• Committee member: Branka Marinović (član povjerenstva)
• Committee member: Zrinka Bukvić Mokos (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Dermatology); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract

Primary cutaneous lymphoma is a rare heterogenous group of extranodal non-Hodgkin's lymphomas of which primary manifestation involve the skin. Primary cutaneous lymphoma consists of two major entities: cutaneous T-cell lymphoma and cutaneous B-cell lymphoma, each further divided into common subgroups. Cutaneous T-cell lymphomas account for the majority of diagnosed cases, with mycosis fungoides and Sézary syndrome being its most important entities. The etiopathogenesis of primary cutaneous lymphoma is relatively unknown and poorly understood. However, recent breakthroughs in research have established an involvement of abnormal inflammatory stimulation and expression of various cytokine cascades, driving tumorigenesis. Given the significant overlaps and resemblances of primary cutaneous lymphoma subtypes in clinical features and immunohistopathological findings, a thorough and comprehensive assessment process is required to correctly diagnose the nature of the tumor, determine the prognosis of the disease, and initiate accurate treatment. Primary cutaneous lymphomas, as rare diseases, require a multidisciplinary approach in diagnosis and treatment. The main goal of treatment in these patients is to improve the quality of live while avoiding diverse toxicities.

Abstract (croatian)

Primarni kožni limfomi su rijetka heterogena skupina ekstranodalnih ne-Hodgkinovih limfoma čija primarna manifestacija uključuje kožu. Primarni kožni limfomi sastoje se od dva glavna entiteta: kožnih T-staničnih limfoma i kožnih B-staničnih limfoma, od kojih je svaki dalje podijeljen u zajedničke podskupine. Kožni T-stanični limfomi čine većinu dijagnosticiranih slučajeva, pri čemu su mycosis fungoides i Sézaryjev sindrom najvažniji entiteti. Etiopatogeneza primarnih kožnih limfoma još uvijek je relativno nepoznata i nedovoljno istražena. Novija istraživanja utvrdila su uključenost abnormalne upalne stimulacije i ekspresije različitih kaskada citokina u tumorogenezi. S obzirom na značajna preklapanja i sličnosti primarnih podtipova kožnih limfoma u kliničkim značajkama i imunohistopatološkim nalazima, potreban je temeljit i sveobuhvatan pristup bolesnicima kako bi se ispravno dijagnosticirala priroda tumora, odredila prognoza bolesti i započelo ciljano liječenje. Primarni kožni limfomi kao rijetke bolesti zahtijevaju multidisciplinarni pristup u dijagnostici i liječenju. Glavni cilj liječenja ovih pacijenata je poboljšati kvalitetu života uz izbjegavanje toksičnosti različitih modaliteta liječenja.

• Keywords: primary cutaneous lymphoma; cutaneous T-cell lymphomas; cutaneous B-cell lymphomas; mycosis fungoides; Sézary syndrome; primary cutaneous follicle center lymphoma.
• Keywords (croatian): Primarni kožni limfom; kožni T-ćelijski limfomi; kožni B-ćelijski limfomi; mikozis fungoides; Sézaryjev sindrom; primarni kožni folikularni centarski limfom
• Language: english
• URN:NBN: urn:nbn:hr:105:332582
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-10-18 09:29:29