Next generation in Alzheimer's therapeutic strategies

master's thesis

• Title (croatian): Nova generacija lijekova za Alzheimerovu bolest
• Author: Ophir Shenhav
• Mentor: Marina Boban (mentor)
• Committee member: Marina Boban (predsjednik povjerenstva)
• Committee member: Srđana Telarović (član povjerenstva)
• Committee member: Željka Petelin Gadže (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Neurology); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Neurology

Abstract

Alzheimer's disease (AD) poses a significant challenge in modern healthcare, demanding urgent solutions and a definitive cure.
As the aging population grows and life expectancy increases, the number of individuals affected by this debilitating condition rises, placing a significant burden on healthcare systems worldwide.
Despite extensive research efforts on a global scale, effective treatments for AD remain elusive. This lack of definitive solutions intensifies the urgency to discover breakthrough therapies, as the race against time to combat AD continues.
In recent times, noteworthy progress has been achieved with the approval of new disease-modifying drugs that employ innovative mechanisms of action, addressing diverse hypotheses concerning the development of AD.
This thesis aims to delve into the foundational aspects of AD, encompassing disease's multifactorial elements and intricate mechanisms. Through this exploration, it seeks to offer a comprehensive insight into recent progress, strategies, and the diverse factors influencing pharmaceutical AD treatment.

Abstract (croatian)

Alzheimerova bolest predstavlja značajan izazov u suvremenom zdravstvu koji zahtijeva hitna rješenja, osobito pronalazak novih farmakoloških mogućnosti. S obzirom na to da populacija stari i produljuje se očekivani životni vijek ljudi,
raste i broj pojedinaca pogođenih ovom iscrpljujućom bolesti, što predstavlja značajan teret za zdravstvene sustave diljem svijeta.
Unatoč opsežnim istraživačkim naporima na globalnoj razini, učinkovito liječenje Alzheimerove bolesti je i dalje nedostižno. Nedostatak adekvatne farmakoterapije stavlja imperativ pred znanstvenike za otkrivanjem novih, revolucionarnih lijekova, dok se utrka s vremenom u borbi protiv Alzheimerove bolesti nastavlja.
U posljednje vrijeme postignut je značajan napredak u farmakoterapiji Alzheimerove bolesti s odobravanjem novih lijekova koji mijenjaju tijek bolesti (engl. disease-modifying drugs) time što koriste inovativne mehanizme djelovanjatemeljene na različitim hipotezama nastankaAlzheimerove bolesti.
Ovaj diplomski rad ciljano istražuje temeljne aspekte Alzheimerove bolesti, obuhvaćajući multifaktorijalne elemente i komplicirane hipoteze nastanka bolesti.
Ovim istraživanjem nastoji se ponuditi sveobuhvatan uvid u nedavni napredak, strategije i različite čimbenike koji utječu na razvoj lijekova za liječenje Alzheimerove bolesti.

• Keywords: Alzheimer's disease; Amyloid; Anti amyloid immunotherapy; Drugs; Pharmacological treatments
• Keywords (croatian): Alzheimerova bolest; amiloid; antiamiloidna imunoterapija; lijekovi
• Language: english
• URN:NBN: urn:nbn:hr:105:916686
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-10-21 08:51:36