prikaz prve stranice dokumenta Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study
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Scientific paper - Original scientific paper
Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study
The Lancet Regional Health - Europe, 38 (2024); 100824. https://doi.org/10.1016/j.lanepe.2023.100824
Bugiardini, Raffaele; Cenko, Edina; Yoon, Jinsung; Bergami, Maria; Vasiljevic, Zorana; Mendieta, Guiomar; Zdravkovic, Marija; Vavlukis, Marija; Kedev, Sasko; Miličić, Davor; Badimon, Lina; Manfrini, Olivia

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Bugiardini, R., Cenko, E., Yoon, J., Bergami, M., Vasiljevic, Z., Mendieta, G. ... Manfrini, O. (2024). Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study. The Lancet Regional Health - Europe, 38.. doi: 10.1016/j.lanepe.2023.100824

Bugiardini, Raffaele, et al. "Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study." The Lancet Regional Health - Europe, vol. 38, 2024. https://doi.org/10.1016/j.lanepe.2023.100824

Bugiardini, Raffaele, Edina Cenko, Jinsung Yoon, Maria Bergami, Zorana Vasiljevic, Guiomar Mendieta, Marija Zdravkovic, et al. "Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study." The Lancet Regional Health - Europe 38 (2024). https://doi.org/10.1016/j.lanepe.2023.100824

Bugiardini, R., et al. (2024) 'Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study', The Lancet Regional Health - Europe, 38. doi: 10.1016/j.lanepe.2023.100824

Bugiardini R, Cenko E, Yoon J, Bergami M, Vasiljevic Z, Mendieta G, and sur.. Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study. The Lancet Regional Health - Europe [Internet]. 2024 January [cited 2024 November 29];38. doi: 10.1016/j.lanepe.2023.100824

R. Bugiardini, et al., "Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study", The Lancet Regional Health - Europe, vol. 38, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:973775. [Accessed: 29 November 2024]

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Metadata
Title (english)Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study
AuthorRaffaele Bugiardini
AuthorEdina Cenko
AuthorJinsung Yoon
AuthorMaria Bergami
AuthorZorana Vasiljevic
AuthorGuiomar Mendieta
AuthorMarija Zdravkovic
AuthorMarija Vavlukis
AuthorSasko Kedev
AuthorDavor Miličić
AuthorLina Badimon
AuthorOlivia Manfrini
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: The age-standardized death rates under 65 years from ischemic heart disease in South Eastern Europe are approximately twice as high than the Western Europe average, but the reasons are not completely recognized. The aim of the present study was to address this issue by collecting and analyzing data from a large, multinational cohort. Methods: We enrolled 70,953 Caucasian patients with first acute coronary syndrome, from 36 urban hospital in 7 South Eastern European countries and assessed their life expectancy free of acute coronary syndrome and mortality within 30 days after hospital admission from acute coronary syndrome as estimated in relation to dichotomous categories of traditional risk factors (current smoking, hypertension, diabetes and hypercholesterolemia) stratified according to sex. Findings: Compared with patients without any baseline traditional risk factors, the presence of all four risk factors was associated with a 5-year shorter life expectancy free of acute coronary syndrome (women: from 67.1 ± 12.0 to 61.9 ± 10.3 years; r = -0.089; p < 0.001 and men: from 62.8 ± 12.2 to 58.9 ± 9.9 years; r = -0.096; p < 0.001). Premature acute coronary syndrome (women <67 years and men <63 years) was remarkably related to current smoking and hypercholesterolemia among women (RRs: 3.96; 95% CI: 3.72-4.20 and 1.31; 95% CI: 1.25-1.38, respectively) and men (RRs: 2.82; 95% CI: 2.71-2.93 and 1.39; 95% CI: 1.34-1.45, respectively). Diabetes was most strongly associated with death from premature acute coronary syndrome either in women (RR: 1.52; 95% CI: 1.29-1.79) or men (RR: 1.63; 95% CI: 1.41-1.89). Interpretation: Public health policies in South Eastern Europe should place significant emphasis on the four traditional risk factors and the associated lifestyle behaviors to reduce the epidemic of premature ischemic heart disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleThe Lancet Regional Health - Europe
Numberingvol. 38, 100824
p-ISSN2666-7762
DOIhttps://doi.org/10.1016/j.lanepe.2023.100824
URN:NBNurn:nbn:hr:105:973775
Publication2024-01
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S2666776223002430
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-10-30 14:55:42