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Scientific paper - Original scientific paper
HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis
International Journal of Molecular Sciences, 25 (2024), 2; 882. https://doi.org/10.3390/ijms25020882
Held, Martina; Štingl Janković, Katarina; Šestan, Mario; Šapina, Matej; Kifer, Nastasia; Sršen, Saša; Frković, Marijan; Gagro, Alenka; Grubić, Zorana; Jelušić, Marija

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Held, M., Štingl Janković, K., Šestan, M., Šapina, M., Kifer, N., Sršen, S. ... Jelušić, M. (2024). HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis. International Journal of Molecular Sciences, 25. (2). doi: 10.3390/ijms25020882

Held, Martina, et al. "HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis." International Journal of Molecular Sciences, vol. 25, no. 2, 2024. https://doi.org/10.3390/ijms25020882

Held, Martina, Katarina Štingl Janković, Mario Šestan, Matej Šapina, Nastasia Kifer, Saša Sršen, Marijan Frković, Alenka Gagro, Zorana Grubić and Marija Jelušić. "HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis." International Journal of Molecular Sciences 25, no. 2 (2024). https://doi.org/10.3390/ijms25020882

Held, M., et al. (2024) 'HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis', International Journal of Molecular Sciences, 25(2). doi: 10.3390/ijms25020882

Held M, Štingl Janković K, Šestan M, Šapina M, Kifer N, Sršen S, and sur.. HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis. International Journal of Molecular Sciences [Internet]. 2024 January 10 [cited 2024 December 04];25(2). doi: 10.3390/ijms25020882

M. Held, et al., "HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis", International Journal of Molecular Sciences, vol. 25, no. 2, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:987020. [Accessed: 04 December 2024]

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Metadata
Title (english)HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis
AuthorMartina Held
AuthorKatarina Štingl Janković
AuthorMario Šestan
AuthorMatej Šapina
AuthorNastasia Kifer
AuthorSaša Sršen
AuthorMarijan Frković
AuthorAlenka Gagro
AuthorZorana Grubić
AuthorMarija Jelušić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (english)
Studies concerning the genetic background of IgA vasculitis (IgAV), a small-vessel vasculitis occurring predominantly in childhood, have confirmed that the HLA-DRB1 gene showed a strong association with disease susceptibility. The objective was to investigate human leukocyte antigen (HLA) polymorphisms among Croatian patients with IgAV and their influence on disease susceptibility and clinical heterogeneity. Thus, 130 children with IgAV and 202 unrelated healthy individuals were enrolled in the study. Genomic DNA was extracted from whole peripheral blood, and HLA-A, -B, -DRB1 and -DQB1 gene polymorphism analysis was performed. HLA-A*03 (21.4% vs. 12.38%, p = 0.0092), HLA-B*37 (2.9% vs. 0.2%, p = 0.0054) and HLA-DRB1*12 (3.1% vs. 0.7%, p = 0.0216) alleles were significantly more frequent in IgAV patients than in controls. High-resolution typing revealed significantly higher frequency of HLA-DRB1*10:01 and -DRB1*11:03 among IgAV patients with gastrointestinal manifestations of the disease in comparison to controls (p = 0.0021 and p = 0.0301, respectively), while HLA-DRB1*14:01P occurred significantly more often in the group of patients who developed nephritis during the course of the disease (17.5% vs. 4.5%, p = 0.0006). Our results demonstrated that there is an association of HLA-A*03, HLA-B*37 and HLA-DRB1*12 alleles with susceptibility to IgAV in the examined Croatian pediatric population. Studies which aim to determine the HLA profile may contribute to the elucidation of the genetic background of autoimmune diseases, including IgAV.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 2, 882
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25020882
URN:NBNurn:nbn:hr:105:987020
Publication2024-01-10
ProjectNumber: IP-2019-04-8822
Title (croatian): Histološki, klinički, laboratorijski i genski prediktori ishoda bolesnika s Henoch-Schönleinovom purpurom i nefritisom
Title (english): Histological, Clinical, Laboratory and Genetic Predictors of Outcome in Patients with Henoch-Schönlein Purpura and Nephritis
Acronym: PURPURAPREDICTORS
Leader: Marija Jelušić
Jurisdiction: Croatia
Funding stream: Research Projects
Document URLhttps://www.mdpi.com/1422-0067/25/2/882
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-12-04 12:12:00