Uloga tjelesne aktivnosti u nastanku i liječenju poremećaja mišićno-koštane mase u djece oboljele od kroničnih upalnih bolesti crijeva

doctoral thesis

• Title (english): The role of physical activity in the incidence and treatment of muscle and bone mass disorders in children with inflammatory bowel disease
• Author: Ivana Trivić Mažuranić
• Mentor: Sanja Kolaček (mentor)
• Committee member: Irena Senečić-Čala (predsjednik povjerenstva)
• Committee member: Vesna Kušec (član povjerenstva)
• Committee member: Porin Perić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pediatrics); Zagreb
• Defense date and country: 2024-12-02, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Uvod: Kronične upalne bolesti crijeva (engl. inflammatory bowel disease, IBD) povezane su s nepovoljnim promjenama koštane mineralne gustoće (engl. bone mineral density, BMD) i sastava tijela. Potencijalni blagotvorni učinak tjelesne aktivnosti (engl. physical activity, PA) na mišićno-koštanu masu, aktivnost bolesti i kvalitetu života povezanu sa zdravljem (engl. Health Related Quality of Life, HRQoL) još nije istražen.

Ispitanici i metode: Ukupno 42 pedijatrijska bolesnika s IBD-om u remisiji (u dobi 15,3±2,08 godina; 25 dječaka, 17 djevojčica) uključena su 24-tjedni program tjelovježbe umjerenog intenziteta. Prije i po završetku programa procijenjeni su aktivnost bolesti, PA i HRQoL. Dvoenergetska rendgenska apsorpciometrija cijelog tijela bez glave korištena je za određivanje BMD-a te za procjenu sastava tijela.

Rezultati: Ispitanici s Crohnovom bolešću i dječaci su doživjeli statistički značajno poboljšanje mišićno-koštane mase, dok su ispitanici s drugim podtipovima IBD-a i djevojčice doživjeli poboljšanje samo BMD-a. Svi sudionici studije ostali su u stabilnoj kliničkoj remisiji za vrijeme trajanja istraživanja. Ispitanici s ulceroznim kolitisom i neklasificiranim IBD-om postigli su statistički značajno poboljšanje HRQOL-a.

Zaključak: Program vježbanja umjerenog intenziteta u trajanju 24 tjedna dovodi do statistički značajnog poboljšanja mišićno-koštane mase kod djece s IBD-om u kliničkoj remisiji.

Abstract (english)

Introduction: Inflammatory bowel disease (IBD) is associated with unfavorable changes in bone mineral density (BMD) and body composition. The potential beneficial effect of physical activity (PA) on muscle and bone mass, the activity of the disease and Health Related Quality of Life (HRQoL) has not yet been investigated.

Patients and methods: A total of 42 pediatric IBD patients in remission (aged 15.3±2.08 years; 25 boys, 17 girls) were recruited to participate in a 24-week-long moderate intensity exercise program. Prior to starting the program, and after its’ completion, disease activity, PA and HRQoL were assessed. Total body less head dual energy X-ray absorptiometry was used to measure BMD and to assess body composition.

Results: Patients with Crohn’s disease and male study participants experienced significant improvement of muscle and bone mass, whilst patients with other IBD subtypes and female patients experienced improvement solely in BMD. All study participants remained in stable clinical remission. Patients with ulcerative colitis and unclassified IBD achieved a significant improvement in HRQOL.

Conclusions: A 24-week-long moderate intensity exercise program leads to a significant improvement in muscle and bone mass amongst children with IBD in clinical remission.

• Keywords: kronične upalne bolesti crijeva; djeca; mišićno-koštana masa; sastav tijela; tjelesna aktivnost
• Keywords (english): inflammatory bowel disease; children; muscle and bone mass; body composition; physical activity
• Language: croatian
• URN:NBN: urn:nbn:hr:105:093357
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 123 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-12-06 09:23:33