Urine high–sensitive troponin I in children cannot offer an applicable alternative to serum

Scientific paper - Original scientific paper

• Author: Matija Bakoš
• Author: Daniel Dilber
• Author: Anamarija Jazbec
• Author: Tomo Svaguša
• Author: Ana-Meyra Potkonjak
• Author: Duje Braovac
• Author: Željko Đurić
• Author: Andrea Radeljak
• Author: Ana Lončar Vrančić
• Author: Hrvoje Vraneš
• Author: Slobodan Galić
• Author: Milivoj Novak
• Author: Ingrid Prkačin
• Author's institution: University of Zagreb; School of Medicine; (Department of Pediatrics)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract (english)

Introduction: In children, congenital heart defects represent the primary cause of increased serum troponin I. The elimination process of cardiac troponin I from the bloodstream and the factors influencing this process remain unknown. The objective of this study was to explore the role of troponin I as an indicator of cardiac damage in children both in serum and urine, a concept previously investigated in adults.

Methods: Our prospective study involved 70 children under 24 months of age. The first group underwent ventricular septal defect repair, while the second group involved children who had undergone partial cavopulmonary anastomosis. For these groups, urine and serum troponin I were assessed on four occasions. The third group, consisting of healthy children, underwent a single measurement of urine troponin I.

Results: Serum troponin I values exhibited an expected elevation in the early postoperative period, followed by a return to lower levels. Significantly higher concentrations of serum troponin I were observed in the first group of children (p < 0.05). A positive correlation was found between troponin I in the first three measurements and cardiopulmonary bypass and aortic cross-clamping time. There was no discernible increase in urine troponin I directly related to myocardial damage; troponin I couldn't be detected in most urine samples.

Discussion: The inability to detect troponin I in urine remains unexplained. Potential explanatory factors may include the isoelectric point of troponin I, elevated urinary concentrations of salts and urea, variations in urine acidity (different pH levels), and a relatively low protein concentration in urine.

• Keywords (english): cardiac surgery; cardiac troponin I; high-sensitive troponin I; serum; urine
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Frontiers in Cardiovascular Medicine
• Numbering: vol. 11, 1391434
• e-ISSN: 2297-055X
• DOI: https://doi.org/10.3389/fcvm.2024.1391434
• URN:NBN: urn:nbn:hr:105:204401
• Publication: 2024-05-20
• Document URL: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1391434/full
• Type of resource: Text
• Access conditions: Open access
• Created on: 2025-02-03 09:46:07