Neepidermoidni tumori grkljana

master's thesis

• Title (english): Non-epidermoid tumors of the larynx
• Author: Ika Gugić
• Mentor: Drago Prgomet (mentor)
• Committee member: Srećko Branica (predsjednik povjerenstva)
• Committee member: Mirko Ivkić (član povjerenstva)
• Committee member: Drago Prgomet (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Othorhinolaryngology and Head and Neck Surgery); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract

Većina benignih i malignih tumora grkljana je epitelnog porijekla, oni nastaju promjenama u respiratornom epitelu koji prekriva najveći dio površine grkljana. Među benignim tumorima najčešći je papilom, građen od zrelog pločastog epitela koji oblaže fibrovaskularnu stromu. Nastaje kao posljedica infekcije humanim papilomavirusom. Planocelularni karcinom najčešći je maligni tumor grkljana. Najčešće se javlja u pušača. Mali dio tumora ove regije nije epitelnog porijekla, njih zovemo neepidermoidni tumori grkljana. Dijelimo ih na temelju njihova staničnog porijekla na tumore sekretornog porijekla, tumore porijekla vezivnog tkiva, limforetikularnog, melanocitnog ili metastatskog porijekla. Ove rijetke neoplazme čine skupinu bolesti koje se klinički prezentiraju nespecifičnim znakovima i simptomima poput promuklosti, stridora ili disfagije, koji se ujedno javljaju i u bolesnika s planocelularnim karcinomima grkljana. Karakteristični nalaz u oboljelih pacijenata su polipoidne ili submukozne mase koje su ujedno i najčešći razlog kasnog otkrivanja ovih tumora u usporedbi s ulcerativnim lezijama karakterističnim za planocelularni karcinom. Pravodobna dijagnoza ovih tumora iznimno je važna zbog vrlo različitog pristupa u liječenju te različitih prognoza ishoda.

Abstract (english)

Most of the benign and malignant tumors of the larynx are epithelial, they occur as the result of changes in the respiratory epithelium that covers almost the entire larynx. The most common benign tumor is papilloma, composed of mature squamous epithelium that covers the fibrovascular stroma. It occurs as a result of Human papillomavirus infection. Squamous cell carcinoma is the most common malignant tumor of the larynx. Squamous cell carcinoma is most common in smokers. A small part of the tumor in this region is not epithelial and they are called non-epidermoid tumors of the larynx. According to cell origin, non-epidermoid tumors are classified into secretory, connective tissue, lymphorecticular, melanoma, or metastatic carcinoma. These rare neoplasms are a group of diseases that present with nonspecific clinical signs and symptoms, such as hoarseness, stridor, or dysphagia. Those symptoms also present in patients with squamous cell carcinoma of the larynx. Polypoid and submucosal lesions of the larynx are characteristic findings in these tumors, and probably the reason for late diagnosis in comparison to ulcerative lesions of squamous cell carcinoma. Timely recognition of these tumors is extremely important due to different approaches in the treatment and prognosis.

• Keywords: neepidermoidni tumori grkljana-dijagnoza; patohistološke značajke; liječenje
• Keywords (english): non-epidermoid tumors of larynx-diagnosis; pathology; treatment
• Language: croatian
• URN:NBN: urn:nbn:hr:105:766046
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-08-21 11:10:15