Akutna upala gušterače

master's thesis

• Title (english): Acute pancreatitis
• Author: Filip Cetinić
• Mentor: Vesna Degoricija (mentor)
• Committee member: Neven Ljubičić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Vesna Degoricija (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Akutna upala gušterače je složena i potencijalno teška bolest. Incidencija bolesti je u porastu, prvenstveno zbog povećane izloženosti čimbenicima rizika kao i zbog očekivanog duljeg trajanja života. Uzroci akutne upale gušterače su mnogobrojni, a najčešći su kolelitijaza i alkoholizam. Točan i potpun mehanizam nastanka akutne upale gušterače i dalje nije u cijelosti poznat. Međutim, u zadnje vrijeme je došlo do značajnog preokreta u shvaćanju patogeneze. U tom novom konceptu središnje mjesto zauzima oštećenje acinarne stanice i posljedični razvoj upalne kaskade. Akutna upala gušterače može biti ili blaga do srednje teška (intersticijska) ili teška (nekrotizirajuća). Glavni simptom akutne upale gušterače u oba oblika je intenzivna bol, najčešće lokalizirana u epigastriju, dok ostali simptomi ovise o težini bolesti. Liječnicima danas na raspolaganju stoje brojne dijagnostičke metode, ali je detaljan klinički pregled i dalje od iznimne važnosti. Uzimajući to u obzir, najčešće se u dijagnostici mjere razine aktivnosti serumskih lipaza i amilaza, a CT se smatra "zlatnim standardom" za pouzdanu dijagnozu teške akutne upale gušterače. Procjena težine bolesti je izuzetno bitna pa tako danas postoje mnogi sustavi pomoću kojih se može precizno odrediti težina ove bolesti, kao što su Ransonovi kriteriji i APACHE II sustav. Iako specifično liječenje ovisi o težini bolesti, glavni ciljevi liječenja su univerzalni, a to su: ograničavanje sustavnih komplikacija, prevencija razvoja nekroze gušterače i sprječavanje infekcije u slučajevima kada je nekroza već nastala. Središnje mjesto u terapiji danas zauzima potporno liječenje i sprječavanje komplikacija. Komplikacije akutne upale gušterače mogu biti lokalne i sustavne. Najopasnija lokalna komplikacija je inficirana nekroza, dok je najopasnija sustavna komplikacija višeorgansko zatajenje. Prognoza bolesti ovisi o težini i prisutnosti komplikacija. Najgoru prognozu ima teška akutna upala gušterače s razvijenom inficiranom nekrozom kod koje mortalitet može iznositi čak 25%.

Abstract (english)

Acute pancreatitis is a complex and potentially severe disease. The incidence of the disease is on the rise, primarily because of an increased exposure to risk factors as well as an increased life expectancy. There are numerous causes of acute pancreatitis of which the most common are cholelithiasis and alcoholism. The exact and complete pathogenetic mechanism of acute pancreatitis is still not entirely known. However, recently there has been a significant shift in the perceiving of this mechanism. The damage to the acinar cell and the subsequent inflammatory cascade is the basic process in this new concept. Acute pancreatitis can be mild to moderately severe (interstitial) or severe (necrotizing). The basic symptom of either degree of the disease severity is an intensive pain, most often localised in the epigastrium, while other symptoms vary according to the disease severity. Doctors today have numerous diagnostic "tools" at their disposal, but the thorough physical examination is still of a paramount importance. Considering that, measuring serum lipase and amylase concentrations is still the most often used diagnostic method, while the CT-scan is regarded as the "gold standard" for a reliable diagnosis of severe acute pancreatitis. Assessing the disease severity is very important and there are numerous systems which can be used for the accurate assessment of the disease severity, such as the Ranson's criteria and the APACHE II score. Although the specific therapy depends on the disease severity, the main therapeutic goals are universal and they are: limiting systemic complications, the prevention of development of pancreatic necrosis and the prevention of infection when the necrosis has already occurred. Today, the therapy is based on the supportive care and the prevention of complications. Complications of acute pancreatitis can be local and systemic. The most dangerous local complication is the infected necrosis, whilst the most dangerous systemic complication is a multi-organ failure. The prognosis of the disease depends on the disease severity as well as the presence of complications. Acute pancreatitis with the developed infected necrosis has the worst prognosis with an overall mortality of up to 25%.

• Keywords: akutna upala gušterače; kolelitijaza; alkoholizam; upalna kaskada; bol; težina bolesti; inficirana nekroza; komplikacije
• Keywords (english): acute pancreatitis; cholelithiasis; alcoholism; inflammatory cascade; pain; disease severity; infected necrosis; complications
• Language: croatian
• URN:NBN: urn:nbn:hr:105:636515
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-08-22 11:35:27