Toll like receptors (TLR) in autoimmune disease and atherosclerosis

master's thesis

• Author: Marina Ljubica Sopta
• Mentor: Jasenka Markeljević (mentor)
• Committee member: Mislav Vrsalović (predsjednik povjerenstva)
• Committee member: Jadranka Sertić (član povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Immunology

Abstract

Chronic inflammation and/or autoimmune responses have been associated with a number of diseases including atherosclerosis, scleroderma, Sjogren’s syndrome, systemic lupus erythematosus (SLE) and others. Toll-like receptors (TLRs) are important receptors that recognize both exogenous and endogenous ligands and initiate signaling cascades, involving numerous adaptors, kinases and transcription factors, which ultimately lead to enhanced gene expression of cytokines and other factors associated with chronic inflammation or autoimmune reactions. TLRs represent a family of membrane bound receptors that are part of the larger pattern recognition receptor (PRR) family. TLRs play a role in both innate and adaptive immunity. As such TLRs are central to the processes of chronic inflammation and autoimmunity. In this review I discuss the molecular aspects of TLR signalling and how TLRs are involved in the pathogenesis of atherosclerosis and autoimmune diseases.

• Keywords: toll-like receptors; atherosclerosis; autoimmune disease; immunity
• Language: english
• URN:NBN: urn:nbn:hr:105:173354
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-08-30 11:21:26