Uloga debljine u nastanku i liječenju atrijske fibrilacije

master's thesis

• Title (english): Role of obesity in the etiology and treatment of atrial fibrillation
• Author: Mirna Čilić
• Mentor: Martina Lovrić Benčić (mentor)
• Committee member: Maja Čikeš (predsjednik povjerenstva)
• Committee member: Marko Jakopović (član povjerenstva)
• Committee member: Martina Lovrić Benčić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Debljina kao kronična bolest 21. stoljeća nije samo estetski problem, nego i zdravstveni poremećaj. Zbog velikog utjecaja na kardiovaskularni sustav zadobila je pažnju brojnih znanstvenika. Broj kardiovaskularnih bolesnika iz dana u dan sve više raste zbog sjedilačkog načina života. Fibrilacija atrija je danas najčešća postojana aritmija i sve više ljudi obolijeva od nje. Mnogi znanstvenici su nastojali povezati ove dvije bolesti. Rezultati većine istraživanja pokazali su pozitivnu povezanost debljine i njezinih patofizioloških procesa sa nastankom fibrilacije atrija i njezinih komplikacija. Usprkos tome, neke kliničke studije pokazuju kontradiktorne rezultate. Kako bismo sami provjerili ovu tezu, svoje pacijente na Klinici za bolest srca i krvnih žila na KBC-u Rebro podvrgnuli smo „Školi mršavljenja“. U našem istraživanju je sudjelovalo 79 pretilih pacijenata. Rezultat istraživanja pokazao je da strukturni plan gubitka tjelesne težine smanjuje kardiometabolički rizik, a sa time i inzulinsku rezistenciju te upalne procese u organizmu za koje se vjeruje da su okidač za nastanak FA. Naše istraživanje pridonijelo je sveukupnom razumijevanju antiaritmičkog utjecaja smanjenja tjelesne težine.

Abstract (english)

Obesity as a chronic illness of the 21st century is not just an aesthetic problem but also a health disorder. Due to its great influence on the cardiovascular system, it has drawn attention of many scientists. The number of cardiovascular patients is increasing every day because of a sedentary lifestyle. Atrial fibrillation is the most frequent type of cardiac rhythm disorder today and more and more people suffer from it. Many scientists have been trying to link these two diseases. The results of most studies show a positive correlation of obesity and it’s pathophysiological processes with the formation of atrial fibrillation and its complications. Nonetheless, some clinical studies show contradictory results. In order to test this thesis, the patients treated at the Clinic for heart and blood vessel disease at the University Hospital Rebro underwent “Structured weight loss program”. 79 obese patients participated in our study. The results of the research show that the “Structured weight loss program” reduces cardiometabolic risk and therefore also insulin resistance and inflammatory processes in the body, believed to be the trigger for atrial fibrillation. Our research has contributed to the overall understanding of the antiarrhythmic effect of weight reduction.

• Keywords: pretilost; ITM; fibrilacija atrija; kardiovaskularni bolesnici
• Keywords (english): obesity; atrial fibrillation; cardiovascular patients
• Language: croatian
• URN:NBN: urn:nbn:hr:105:014921
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-11-08 13:51:22