Depresija i bolesti srca

master's thesis

• Title (english): Depression and heart diseases
• Author: Matea Raič
• Mentor: Miro Jakovljević (mentor)
• Committee member: Davor Miličić (predsjednik povjerenstva)
• Committee member: Dražen Begić (član povjerenstva)
• Committee member: Miro Jakovljević (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Psychiatry and Psychological Medicine); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry

Abstract

Depresija je jedan od najučestalijih duševnih poremećaja i nalazi se na četvrtom mjestu uzroka nesposobnosti zbog bolesti sa stalnom tendencijom rasta. Depresija je čest poremećaj u kardijalnih bolesnika, s prevalencijom od 20 do 45 %, što je mnogo češće nego u općoj populaciji. Znanstvene studije su pokazale da komorbidna stanja između depresije i kardiovaskularnih bolesti imaju visoku prevalenciju i česta je pojava koegzistiranja ova dva entiteta. Mehanizmi razvoja komorbiditeta su različiti, a uključuju gensku predispoziciju za duševne i kardiovaskularne bolesti, tipove ličnosti, izloženost stresu, te povećanu učestalost nezdravih životnih navika i stilova življenja. Patofiziološka povezanost depresije i bolesti srca odnosi se na disfunkciju autonomnoga živčanog sustava, hiperaktivnost osi hipotalamus-hipofiza-nadbubrežna žlijezda (HHN os), endotelnu disfunkciju krvožilja, upalna stanja, poremećaj trombocitne aktivnosti, homocisteinemiju te brojne psihosocijalne faktore. Istovremeno liječenje oba entiteta zahtijeva pažljivost liječnika pri odabiru farmakološke terapije zbog složenih interakcija između psihotropnih i kardioloških lijekova. Osim farmakološke terapije, nužna je i psihoterapija kako bi se spriječila pojava rezidualnih simptoma i osigurala adekvatna kvaliteta života depresivnih kardioloških bolesnika.

Abstract (english)

Depression is one of the most common mental health disorders and is ranked fourth in the cause of disability due to illness with constant growth tendency. Depression is a common disorder in cardiovascular patients with a prevalence of 20% to 45%, which is much more frequent than in the general population. Scientific studies have shown that the comorbid states between depression and cardiovascular disease have high prevalence and there is a common phenomenon of coexistence between these two entities. Mechanisms for the development of comorbidity are diverse and include genetic predisposition for mental and cardiovascular diseases, personality types, stress exposure, and increased incidence of unhealthy lifestyles.
The pathophysiological association of depression and heart disease is related to autonomic nervous system dysfunction, hyperactivity of the hypothalamus-pituitary-adrenal gland (HHN os), endothelial dysfunction of the blood vessels, inflammatory conditions, platelet function, homocysteineemia, and numerous psychosocial factors. At the same time, treatment of both entities requires attentiveness of the physician when choosing pharmacological therapy due to complex interactions between psychotropic and cardiological drugs. In addition to pharmacological therapy, psychotherapy is also needed to prevent the occurrence of residual symptoms and to provide adequate quality of life for depressed cardiovascular patients.

• Keywords: depresija; bolesti srca; komorbiditet; psihokardiologija
• Keywords (english): depression; heart diseases; comorbidity; psychocardiology
• Language: croatian
• URN:NBN: urn:nbn:hr:105:728736
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-11-24 10:40:34