Prognostički faktori oboljelih od raka vrata maternice kliničkog stadija IA2-IB kod kojih je provedeno radikalno kirurško liječenje

master's thesis

• Title (english): Prognostic factors for stage IA2-IB cervical cancer patients who underwent radical surgery
• Author: Daren Lučinger
• Mentor: Goran Vujić (mentor)
• Committee member: Mario Ćorić (predsjednik povjerenstva)
• Committee member: Dinka Pavičić-Baldani (član povjerenstva)
• Committee member: Goran Vujić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Rak vrata maternice treći je po učestalosti maligni ginekološki tumor u Hrvatskoj nakon karcinoma endometrija i malignih tumora jajnika, te osmi po učestalosti od svih malignoma u žena. Karcinom cerviksa tumor je čiji se stadij određuje klinički. Na osnovi kliničkog stadija donosi se odluka o liječenju. Liječenje se provodi kirurški, kemoiradijacijom ili kombinirano. Karcinom se smatra operabilnim do i uključujući FIGO stadij IIA. Cilj ovog istraživanja bio je utvrditi utjecaj najvažnijih prognostičkih faktora na pojavnost recidiva žena oboljelih od karcinoma vrata maternice kod kojih je provedeno radikalno kirurško liječenje. Ispitanice su podijeljene u dvije glavne skupine. U prvoj skupini su pacijentice s recidivom bolesti, a u drugoj bez recidiva. Uspoređivani su prognostički faktori za ove dvije istraživane skupine. Približno 10% ispitanica razvilo je recidiv karcinoma. Statistička analiza podataka pokazala je da slijedeće varijable značajno utječu na pojavnost recidiva kod žena oboljelih od karcinoma vrata maternice: dob pri dijagnozi, veličina tumora, dubina invazije tumora u stromu, zahvaćenost istmusa tumorom, limfokapilarna invazija tumora i metastaze tumora u limfne čvorove. Pacijentice koje su oboljele u starijoj dobi, te pacijentice s većim tumorom i duboljom invazijom strome imaju veću šansu da razviju recidiv bolesti. Ispitanice sa limfokapilarnom invazijom tumora, zahvaćenim istmusom maternice, te metastazama u limfnim čvorovima češće su razvijale recidiv karcinoma vrata maternice, za razliku od ispitanica bez navedenih rizičnih čimbenika.

Abstract (english)

Cervical cancer is the third most common malignant gynecological tumor in Croatia and the eighth most common of all malignant tumors in women. It is directly associated to HPV infection. Cervical cancer is a clinically staged tumor. For early cervical cancer the choice between surgical treatment and primary radiotherapy has to be made. The tumor is considered operable up to FIGO stage IIA. The primary goal of this research was to determine which factors affect the prognosis of women with cervical cancer clinically staged from IA2 to IB2 that have been treated by radical surgery. The women were divided into two groups, one with recurrence and one without. The prognostic factors were compared between the two groups. The noticed percentage of recurrence was approximately 10%. The comparison of women with and without recurrence showed statistical significance in certain factors; age when diagnosed, size of tumor, depth of stromal invasion, lymphovascular space invasion, infiltration of the uterine isthmus and lymph node metastases. Older women, those with larger tumor and with deeper stromal invasion had recurrence more often. Also, it was statistically noted that the women with lymphovascular space invasion, infiltrated isthmus of the uterus, and lymph node metastases were more likely to get a recurrence when compared to women without the previously mentioned factors.

• Keywords: karcinom vrata maternice; radikalno kirurško liječenje; prognostički faktori
• Keywords (english): cervical cancer; radical surgery; prognostic factors
• Language: croatian
• URN:NBN: urn:nbn:hr:105:150041
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-01-08 10:46:49