Kutane manifestacije eritemskog lupusa

master's thesis

• Title (english): Cutaneous manifestations of lupus erythematosus
• Author: Valentina Cigić
• Mentor: Branka Marinović (mentor)
• Committee member: Zrinka Bukvić Mokos (predsjednik povjerenstva)
• Committee member: Krešimir Kostović (član povjerenstva)
• Committee member: Branka Marinović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Dermatology); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract

Eritemski lupus kronična je, upalna multisistemska bolest koja obuhvaća široki spektar simptoma. Simptomi variraju od blagih kutanih manifestacija kod nekih oblika kutanog eritemskog lupusa (CLE) do težih oštećenja organa u sistemskom obliku lupusa (SLE). Etiologija je i dalje nepoznata, iako se okolišni, biološki i genetski čimbenici istražuju kao mogući uzroci ili okidači. Gilliamov klasifikacijski sustav iz 1977. godine napravio je razdiobu između kutanih manifestacija na one specifične za lupus erythematosus i onih koje nisu specifične za tu bolest. Kasnije su Kuhn i sur. 2004. godine razvili noviji sustav naziva „Düsseldorfska klasifikacija“ prema kojoj se CLE dijeli na akutni kutani eritemski lupus (ACLE), subakutni CLE (SCLE), kronični CLE (CCLE) te noviju podskupinu koja je nazvana intermitentni kutani eritemski lupus (ICLE). Kronični kutani lupus obuhvaća diskoidni kutani lupus (DLE) s njegovim podtipovima te lupus erythematosus profundus (LEP) i chilblain lupus (CHLE). Dijagnoza ovih oblika zahtijeva klinički pregled, laboratorij, histologiju, serologiju, povremeno DIF uz što se sve nastoji isključiti sustavnu bolest. Liječenje kutanog eritemskog lupusa uključuje edukaciju bolesnika o zaštiti od sunca te lokalne i sustavne lijekove. Sistemska terapija koristi se kod proširene bolesti, oblika koji regrediraju ožiljcima te refraktornih na prijašnje liječenje.

Abstract (english)

Lupus erythematosus (LE) is chronic, inflammatory multisystem disease which encompasses a wide range of presenting symptoms. Symptoms vary from mild cutaneous manifestations in some subsets of cutaneous LE (CLE) to severe, life-threatening internal organ damage in systemic LE (SLE). The etiology of LE remains unknown, although the environmental, viral and genetic factors are taken into consideration as causes or precipitating factors of this disease. Classification system which divides cutaneous manifestation into LE-specific and LE-nonspecific was developed by Gilliam in 1977. Later Kuhn and al. developed modified system named „ Düsseldorf Classifications of Cutaneous Lupus Erythematosus 2003.”. This system divided CLE into acute cutaneous LE (ACLE), subacute cutaneous LE (SCLE), chronic cutaneous LE (CCLE), and intermittent CLE (ICLE). Chronic cutaneous lupus includes discoid LE (DLE), lupus erythematosus profundus (LEP) and chilblain LE (CHLE). Diagnosis of these subtypes requires proper physical exam, laboratory studies, histology, antibody serology, and occasionally direct immunofluorescence, while ensuring to exclude systemic disease. Treatment of cutaneous lupus consists of patient education on proper sun protection along with appropriate topical and systemic agents. Systemic agents are indicated in cases of widespread, scarring, or treatment-refractory disease.

• Keywords: eritemski lupus; kutani eritemski lupus; klasifikacijski sustav; akutni kutani eritemski lupus; subakutni kutani eritemski lupus; kronični kutani eritemski lupus; intermitentni kutani eritemski lupus
• Keywords (english): lupus erythematosus; cutaneous lupus erythematosus; classification system; acute cutaneous lupus erythematosus; subacute cutaneous lupus erythematosus; chronic lupus erythematosus; intermittent lupus erythematosus
• Language: croatian
• URN:NBN: urn:nbn:hr:105:469642
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-20 09:44:16