Title Individualni pristup prehrani kod poremećaja središnjeg živčanog sustava Title (english) Individual approach to nutrition in CNS disorders Author Iva Lukačević Mentor Donatella Verbanac (mentor)Committee member Željko Krznarić (predsjednik povjerenstva)Committee member Ivančica Delaš (član povjerenstva)Committee member Donatella Verbanac (član povjerenstva)Granter University of Zagreb Defense date and country 2018-07-13, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Poremećaji središnjeg živčanog sustava predstavljaju heterogenu skupinu poremećaja koja obuhvaća i neurološke i psihijatrijske entitete. Globalnim porastom pre-valencije poglavito depresije, ali i Alzheimerove demencije i poremećaja iz spektra pervazivnih razvojnih poremećaja, poremećaji SŽS-a sve više dolaze u fokus medicinske i šire zajednice. Pristupom tehnologijama kao što su sekvenciranje nove generacije, proteomika, metabolomika i drugi alati P4 medicine, otvaraju se vrata novim mogućnostima prevencije, ranog prepoznavanja, dijagnostike i liječenja svih bolesti pa tako i poremećaja središnjeg živčanog sustava. U mehanizme održavanja homeostaze ljudskog organizma ulazi i održavanje homeostaze mikrobiote, a nova znanstvena pitanja otvaraju se u području uloge ljudske mikrobiote u zdravlju i bolesti svoga domaćina. Otkrivene su brojne uloge ljudske crijevne mikrobiote, od održavanja crijevne barijere, proizvodnje neurotransmitera, imunološke uloge, uloge u modulaciji HPA osovine itd. pa sve do uloge u etiopatogenezi poremećaja središnjeg živčanog sustava. Ljudski probavni sustav je na brojne načine povezan sa središnjim živčanim sustavom, kroz osovinu mozak-crijevo, čiji se puni potencijal otkrio tek u novije vrijeme saznanjima o presudnoj ulozi mikrobiote u njenim mehanizmima. Istraživanja donose zanimljive spo-znaje o mnogim zajedničkim karakteristikama nutritivnih profila oboljelih od istih poremećaja SŽS-a, kao što su česta preosjetljivost na gluten i kazein kod oboljelih od shizofrenije i dječjeg autizma, specifičnosti mikrobiote kod oboljelih od depresije, dječjeg autizma i Parkinsonove bolesti, nedostatak ω-3 masnih kiselina, nedostatak vitamina D, nedostatak folata kod oboljelih od shizofrenije i depresije, dobrobit prirodnih fenola u Alzheimerovoj bolesti, uloga osovine mozak-crijevo u Parkinsonovoj bolesti i dr. Otvaraju se vrata potencijalno novim dijetoterapijskim opcijama u liječenju ovih poremećaja i zasigurno će translacijom u kliničku praksu u budućnosti osigurati obuhvatniju i kvalitetniju skrb za oboljele.
Abstract (english) CNS disorders represent a heterogeneous group of disorders that include both neurological and psychiatric entities. With the global increase in prevalence of depression particularly, but also Alzheimer's dementia and disorders of pervasive developmental disturbance spectrum, CNS disorders are increasingly coming to focus of the medical and wider community. Through the access to new technologies such as next generation sequencing, proteomics, metabolomics and other tools of P4 medicine, new possibilities arise for prevention, early detection, diagnosis and treatment of all diseases, including CNS disorders. Among the mechanisms of maintenance of the homeostasis of the human organism, the maintenance of microbiota homeostasis is of importance, too, and novel scientific questions about the role of human microbiota in both health and illness of its host arise. Numerous roles of human intestinal microbiota have already been discovered, from intestinal barrier maintenance, neurotransmitter production, role in the immune system, modulation of the HPA axis etc. to its role in CNS disorders. The human digestive system is in many ways associated with the CNS, through the so-called gut-brain axis whose whole potential has only recently been discovered by learning about the crucial role of microbiota in its mechanisms. Many researches bring interesting insight into the many common characteristics of nutritional profiles of patients suffering of the same CNS disorders, such as frequent gluten and casein hypersensitivity in schizophrenia and childhood autism, disturbance in microbiota homeostasis in depression, childhood autism and Parkinson disease, ω-3 fatty acids deficiency, vitamin D deficiency, folate deficiency in schizophrenia and depression, the benefit of natural polyphenols in Alzheimer's disease, the role of the gut-brain axis in Parkinson disease, etc. New possibilities arise when it comes to treating these disorders via nutritional interventions and future translation into clinical practice will most certainly provide more comprehensive and higher standards of quality care for the patients.
Keywords
P4 medicina
poremećaji SŽS-a
prehrana
individualni pristup
Keywords (english)
P4 medicine
CNS disorders
nutrition
individual approach
Language croatian URN:NBN urn:nbn:hr:105:069061 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2018-12-28 10:30:39
