Plućna hipertenzija

master's thesis

• Title (english): Pulmonary hypertension
• Author: Anja Butorac
• Mentor: Neven Tudorić (mentor)
• Committee member: Dario Rahelić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Neven Tudorić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2018-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Plućna hipertenzija (eng. pulmonary hipertension, PH) je stanje povišenog tlaka u plućnoj cikulaciji. PH nastaje kao komplikacija brojnih patoloških stanja i to raznim mehanizmima. Prema patogenezi nastanka Svjetska Zdravstvena Organizacija podijelila je bolest u pet grupa: plućna arterijska hipertenzija (PAH), plućna hipertenzija povezana s bolesti lijevog srca, plućna hipertenzija povezana s hipoksijom, plućna hipertenzija nakon tromboembolijske bolesti (CTEPH) i plućna hipertenzija nepoznata ili multifaktorskog mehanizma djelovanja. Klinička slika ovisi o primarnoj bolesti u podlozi te o progresiji same plućne hipertenzije. Prvi simptom koji pacijenti primjete je progresivna dispneja. Kod pacijenata s PH zbog bolesti lijevog srca mogu se pojaviti znakovi zatajenja lijevog srca. Kod pacijenata s plućnom hipertenzijom iz ostalih skupine javljaju se simptomi zatajenja desnog srca. Dijagnoza se postavlja na temelju anamneze, fizikalnog pregleda i rezultata pretraga. Obrada obuhvaća laboratorijske nalaze, elektrokradigrafiju, CT, MR, scintigrafiju, kateterizaciju desnog srca i ostalo. Liječenje je simptomatsko, samo kod plućne hipertenzije zbog tromboembolijske bolesti je moguće djelovati na uzrok bolesti. Kod takvih pacijenta terapija zlatnog standarda je plućna endarterektomija, a kod pacijenta koji nisu kandidati za taj zahvat može se raditi balon angioplastika plućne arterije. Kod bolesnika s drugim oblicima plućne hipertenzije odobreno je pet kategorija lijekova za snižavanje tlaka u plućnoj cirkulaciji

Abstract (english)

Pulmonary hypertension is a state of increased blood pressure in pulmonary circulation. PH occurs in many different etiopathogenic ways and is a complication of many different pathological states. The World Health Organization has classified PH into five different categories based on their pathogenesis: pulmonary arterial hypertension, pulmonary hypertension associated with left heart disease, pulmonary hypertension associated with hypoxia, thromboembolic pulmonary hypertension (CTEPH) and pulmonary hypertension of unknown origin or due to multifactorial causes. The clinical presentation varies according to the primary cause and disease progression. The first symptom is progressive dyspnea. In patients with pulmonary hypertension associated with left heart disease there can be signs of left heart failure. In other types of PH there can be signs of right heart failure. The clinical diagnosis can be established based on medical history, physical examination, and the results of various diagnostic tests. These include laboratory findings, EKG, CT, MRI, scintigraphy, right heart catheterization, and others. Treatment is symptomatic, only thromboembolic pulmonary hypertension can be treated etiologically. The gold standard for treating such patients is pulmonary endarterectomy, and patients who don't meet the criteria for the procedure can have a pulmonary artery balloon angioplasty performed instead. Other types of pulmonary hypertension are treated with drugs from five different categories for lowering pulmonary blood pressure.

• Keywords: plućna hipertenzija; CTEPH; dispneja; plućna endarterektomija
• Keywords (english): pulmonary hyperension; CTEPH; dyspnea; pulmonary endarterectomy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:908053
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-01-07 10:10:48