Farmakoekonomska analiza terapijskih opcija za liječenje kaheksije u onkoloških bolesnika

master's thesis

• Title (english): Pharmacoeconomic analysis of therapeutic options in cancer-induced cachexia
• Author: Trpimir Matoković
• Mentor: Robert Likić (mentor)
• Committee member: Nadira Duraković (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Robert Likić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2018-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Clinical Pharmacology and Toxicology

Abstract

Starenjem svjetske populacije incidencija malignih bolesti u stalnom je porastu. Kaheksija je jedan od najčešćih sindroma koji prate završne stadije malignih bolesti, a ne postoje unificirane službene smjernice za kliničko procjenjivanje ili terapiju kaheksije. U ovom preglednom radu biti će riječi o patofiziologiji i kliničkoj procjeni onkološke kaheksije, te o trenutno dostupnim terapijskim opcijama za liječenje iste. Cilj rada je usporediti učinkovitost različitih terapijskih opcija (stimulatori apetita, anabolički lijekovi, inhibitori citokina i imunomodulatori te ostale, uglavnom eksperimentalne, terapijske opcije) s njihovom cijenom i razinom dokaza kako bi predložio ekonomski povoljnu alternativu za potencijalna buduća istraživanja. ----- METODE: Pretražene su elektronske baze podataka PubMed i UpToDate.

Abstract (english)

World population is ageing and thus the incidence of malignant diseases is continuously rising. Cachexia is one of the most common syndromes occurring in the end stages of malignant diseases and there are no official guidelines for clinical assessment or therapy for it. This review will discuss pathophysiology, clinical assessment of cancer-induced cachexia and currently available therapeutic options. The focus of this review will be in comparing the effectiveness of available therapy (appetite stimulants, anabolic agents, cytokine and metabolic inhibitors and other, predominantly experimental, drugs) and strength of scientific evidence for the indication of cancer-cachexia with their costs to hopefully propose an economically favorable alternative for future research. ----- METHODS: electronic databases PubMed and UpToDate were searched.

• Keywords: palijativna skrb; kaheksija/terapija; tumor; neoplasma; farmakoekonomika
• Keywords (english): palliative care; cachexia/therapy; tumor; neoplasm; pharmacoeconomics
• Language: croatian
• URN:NBN: urn:nbn:hr:105:674159
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-01-18 10:20:17