Brugadin sindrom

master's thesis

• Title (english): Brugada syndrome
• Author: Karla Kraševac
• Mentor: Martina Lovrić Benčić (mentor)
• Committee member: Davor Puljević (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Martina Lovrić Benčić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2018-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Brugadin sindrom genetski je poremećaj koji se nasljeđuje autosomno dominantno s varijabilnom ekspresijom te je karakteriziran abnormalnim nalazom na površinskom EKG-u. Na EKG nalazu vidi se blok desne grane i elevacija ST segmenta u V1 i V2 odvodima. Najčešće kliničke manifestacije su životno ugrožavajuće aritmije, najčešće ventrikularna fibrilacija ili polimorfna ventrikularna tahikardija. Bolesnici mogu imati još i palpitacije, fibrilaciju atrija, sinkope ili iznenadni srčani arest. Mnogi čimbenici mogu inducirati pojavu tipičnog EKG nalaza; febrilitet, blokatori natrijevih kanala, lijekovi i određena klinička stanja. Dijagnoza se obično postavlja nakon klinički značajnog događaja kada se pacijent prezentira tipičnim EKG nalazom. Terapija je prvenstveno usmjerena na prevenciju iznenadne srčane smrti i prekidanje ventrikularnih aritmija ugradnjom implantabilnog kardioverter-defibrilatora (ICD). Od lijekova mogu se rabiti kinidin i izoproterenol, a može se provesti i radiofrekventna kateterska ablacija.

Abstract (english)

The Brugada syndrome is an autosomal dominant genetic disorder with variable expression characterized by abnormal findings on the surface electrocardiogram. It is associated with an increased risk of ventricular arrhythmias and sudden cardiac death. The ECG findings consist of right bundle branch block and persistent ST segment elevation in leads V1 and V2. Most clinical manifestations are related to life-threatening ventricular arrhythmias, most often ventricular fibrillation or polymorphic ventricular tachycardia. Patients may also present with palpitations, atrial fibrillation, syncope, or sudden cardiac arrest. Many factors may induce the manifestation of typical ECG finding, including fever, sodium channel blockers, drugs, and certain clinical conditions. The diagnosis is often made following a clinically significant event in which the patient has the typical ECG finding. Treatment is primarily focused on prevention of sudden cardiac arrest and termination of any ventricular arrhythmias by implantation of a cardioverter-defibrillator (ICD). Drugs as quinidine and isoproterenol may also be used to treat Brugada syndrome, as well as radiofrequency catheter ablation.

• Keywords: Brugadin sindrom; EKG nalaz; iznenadna srčana smrt; ventrikularna aritmija; kardioverter-defibrilator
• Keywords (english): Brugada syndrome; ECG finding; sudden cardiac death; ventricular arrhythmia; cardioverter-defibrillator
• Language: croatian
• URN:NBN: urn:nbn:hr:105:461528
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-01-23 08:31:37