Image-guided minimally invasive treatment of liver tumors

master's thesis

• Title (croatian): Minimalno invazivno liječenje tumora jetre navođeno metodama slikovne dijagnostike
• Author: Christopher Lambers
• Mentor: Boris Brkljačić (mentor)
• Committee member: Boris Brkljačić (predsjednik povjerenstva)
• Committee member: Gordana Ivanac (član povjerenstva)
• Committee member: Milan Radoš (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Radiology); Zagreb
• Defense date and country: 2018-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiotherapy and Oncology

Abstract

Hepatocellular carcinoma (HCC) is the 6th most common cause of cancer worldwide and contributes to 9% of the global mortality burden attributed to cancer. The limited options of classic systemic cancer therapies, the strict criteria for surgical resection and the global shortage of donor organs for transplantation have led to a search for alternative treatment modalities. Local image-guided, minimally invasive therapies have successfully filled the gap as therapeutic options for HCC, establishing themselves in practice guidelines across the world. Image-guided, minimally invasive therapies encompass local ablative modalities including Radiofrequency ablation (RFA), Cryotherapy, Microwave ablation (MWA), Laser ablation (LA) and High-intensity focused Ultrasound (HIFU) as well as intra-arterial treatment modalities such as transarterial chemoembolization (TACE), transarterial bland embolization (TAE) and transarterial radioembolization (TARE). Both ablative and transarterial therapies have revolutionized the management of HCC. This review article highlights some of the technical aspects of these therapies and provides up to date scientific evidence for their clinical use.

Abstract (croatian)

Hepatocelularni karcinom (HCC) je 6. po redu najčešći uzrok raka u svijetu i doprinosi do 9% globalnog tereta smrtnosti koja se pripisuje raku. Ograničene opcije klasičnih sistemskih terapija protiv raka, strogi kriteriji kirurških resekcija i globalni nedostatak donora organa za transplantaciju su doveli do potrage za alternativnim načinima liječenja. Lokalne minimalno invazivne terapije navođene slikom su uspješno ispunile prazninu u opcijama liječenja HCC, uspostavivši se u smjernicama za liječenje diljem svijeta. Minimalno invazivne terapije navođene slikom obuhvaćaju lokalne modalitete ablacije uključujući radiofrekventnu ablaciju (RFA), krioterapiju, mikrovalnu ablaciju (MWA), ablaciju laserom (LA) i ultrazvuk visokog intenziteta (HIFU) uz, također, intra-arterijske metode liječenja kao što su transarterijska kemoembolizacija (TACE), transarterijska bland embolizacija (TAE) i transarterijska radioembolizacija (TARE). Ablacijsko i transarterijsko liječenje su revolucionarizirali vođenje HCC. Ovaj pregledni članak naglašava neke od tehničkih aspekata tih terapija i pruža najnovije znanstvene dokaze za njihovo kliničko korištenje.

• Keywords: hepatocellular carcinoma (HCC); radiofrequency ablation (RFA); cryotherapy; microwave ablation (MWA); laser ablation (LA); high-intensity focused ultrasound (HIFU); transarterial chemoembolization (TACE); transarterial bland embolization (TAE); transarterial radioembolization (TARE)
• Keywords (croatian): hepatocelularni karcinom (HCC); radiofrekventna ablacija (RFA); krioterapija; mikrovalna ablacija (MWA); ablacija laserom (LA); ultrazvuk visokog intenziteta (HIFU); transarterijska kemoembolizacija (TACE); transarterijska bland embolizacija (TAE); transarterijska radioembolizacija (TARE)
• Language: english
• URN:NBN: urn:nbn:hr:105:579490
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Public note: Pohranitelj objekta dodao ključne riječi.
• Created on: 2019-04-18 08:09:48