Učinci fitokanabinoda na endokanabinoidni sustav

master's thesis

• Title (english): Effects of phytocannabinoids on endocannabinoid system
• Author: Tin Horvatić
• Mentor: Ognjen Brborović (mentor)
• Committee member: VLADIMIR TRKULJA (predsjednik povjerenstva)
• Committee member: Vera Musil (član povjerenstva)
• Committee member: Ognjen Brborović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Social Medicine and Health Care Organization); Zagreb
• Defense date and country: 2019-09-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Social Medicine

Abstract

Iako je biljka Cannabis sativa poznata od davnina kao lijek a danas uglavnom kao rekreacijska droga, tek u zadnjih nekoliko desetljeća, otkrićem endokanabinoidnog sustava dobiveni su prvi znanstveni dokazi farmakološkog i fiziološkog djelovanja njenih aktivnih spojeva, fitokanabinoida. Endokanabinoidni sustav je naziv za kompleksan neuromodulacijski sustav, usko gledano sastavljen od dva receptora, CB1 i CB2 te dva endogena liganda, endokanabinoida AEA i 2-AG. Endokanabinoidni sustav sudjeluje u mnogim procesima od kojih su neki neurotransmiterska regulacija, imunomodulacija, karcinogeneza i nocicepcija. Osim endokanabinoida, endokanabinoidni sustav također mogu modulirati i fitokanabinoidi. Do danas, prepoznato je i izolirano otprilike 120 različitih fitokanabinoida čiji se in vitro i in vivo učinci često ne mogu predvidjeti zbog kompleksnog odnosa s endokanabinoidnim sustavom. Δ9-THC i CBD su najistraživaniji fitokanabinoidi i posebno zanimljivi zbog obećavajućih terapijskih mogućnosti.

Abstract (english)

Although the plant Cannabis sativa has been known for a long time as a medicine and today mostly as a recreational drug, only in the last few decades, with the discovery of the endocannabinoid system, the first scientific evidence was obtained of the pharmacological and physiological activity of its active compounds, phytocannabinoids. The endocannabinoid system is the name for a complex biological system, in the narrow sense, composed of two receptors, CB1 and CB2, and two endogenous ligands, the endocannabinoids AEA and 2-AG. The endocannabinoid system is involved in many processes, some of which are neurotransmitter regulation, immunomodulation, carcinogenesis and nociception. In addition to endocannabinoids, the endocannabinoid system can also be modulated by phytocannabinoids. To date, approximately 120 different phytocannabinoids have been recognized and isolated, whose in vitro and in vivo effects are often not predictable due to their complex relationship with the endocannabinoid system. Δ9-THC and CBD are the most studied phytocannabinoids and especially interesting because of their promising therapeutic possibilities.

• Keywords: Cannabis sativa; fitokanabinoidi; endokanabinoidni sustav
• Keywords (english): Cannabis sativa; phytocannabinoids; endocannabinoid system
• Language: croatian
• URN:NBN: urn:nbn:hr:105:144551
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-02-03 14:55:50