Terapijski potencijal matičnih stanica u regenerativnoj medicini

master's thesis

• Title (english): Therapeutic potential of stem cells in regenerative medicine
• Author: Marko Grgić
• Mentor: Filip Sedlić (mentor)
• Committee member: Maja Sirotković Skerlev (predsjednik povjerenstva)
• Committee member: Jasmina Marić Brozić (član povjerenstva)
• Committee member: Filip Sedlić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pathophysiology); Zagreb
• Defense date and country: 2019-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathophysiology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Cytology, Histology and Embryology

Abstract

U medicini se ostvarilo zaista izvanrednih dostignuća, međutim još uvijek su neke bolesti potpuna nepoznanica, u smislu liječenja, ali i u smislu njihove etiologije i patofiziologije. Matične stanice pružaju nove mogućnosti koje se danas sve više nastoje izučiti kako bi se riješili ti problemi. Danas se koristi izrazito velik broj matičnih stanica, a osnovne su embrionalne matične stanice, tkivno specifične matične stanice, mezenhimalne matične stanice, matične stanice pupkovine, matične stanice koštane srži i inducirane pluripotentne matične stanice. Sva istraživanja su usmjerena ka njihovom korištenju u regeneraciji tkiva i organa. U ovom diplomskom radu bavit ću se primjerima korištenja matičnih stanica, kakva su otkrića već napravljena, koja su tek u začecima i koja će se, nadam se, ostvariti u budućnosti. Dotaknut ću se svih velikih skupina matičnih stanica te ću pokušati staviti istraživanja koja se njima bave u okvire medicine u Hrvatskoj, ali i svijetu te dati naglasak na važnosti tih istraživanja i njihovih mogućih pozitivnih ishoda. Također ću istaknuti i potencijalne opasnosti matičnih stanica, kao i negativnosti njihovog korištenja, ne samo u medicinskom nego i u ekonomskom smislu. U konačnici, pokušat ću dati što bolji pregled trenutačnog stanja regenerativne medicine i eventualnih daljnjih koraka koje treba napraviti.

Abstract (english)

In medicine, remarkable achievements have come to fruition, but there are still some illnesses of complete ignorance in terms of treatment, but also in terms of their etiology and pathophysiology. Stem cells provide new opportunities that are increasingly being studied today to solve these problems. Today, a large number of stem cells, embryonic stem cells, tissue specific stem cells, mesenchymal stem cells, umbilical chord stem cells, bone marrow stem cells, and induced pluripotent stem cells are used. All trials are focused on their use in tissue and organ regeneration. In this graduate thesis I will discuss the examples in which stem cells are used, what are the discoveries already made, which are only in the foreseeable future and which, hopefully, will be realized in the future. I will present all major groups of stem cells and try to put research in the medical framework of Croatia, but also of the world to give an emphasis to the importance of these researches and their possible positive outbreaks. I will also highlight the potential dangers of stem cells, as well as the negatives of their use, not only in medical but also in economic terms. Ultimately, I will try to give a better overview of the current regenerative medicine states and any further steps to be taken.

• Keywords: matična stanica; regenerativna medicina
• Keywords (english): stem cell; regenerative medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:371903
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-04-28 11:11:49