Utjecaj konzumacije vina na strukturu i metabolizam kosti

professional thesis

• Author: Zvonimir Kutleša
• Mentor: Tomislav Đapić (mentor)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2015-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Orthopedics

Abstract

Umjerena konzumacija vina pokazuje nekoliko blagotvornih učinaka na kost kao smanjeni rizik od gubitka koštane mase i prijeloma kosti. Vino je bogato fenolima, snažnim fitoestrogenima i prirodnim antioksidansima koji pridonose zaštiti kosti. Fenoli koji se nalaze u vinu djeluju kao mješavina fenola i spojeva polifenola otopljeni u alkoholnom mediju koji je važan za njihovu djelotvornost. Cilj ovog rada je bio dati pregled dosadašnjih spoznaja o mehanizmima pomoću kojih je konzumacija vina uključena u zaštitu koštanog sustava. Pregledom literature pronađena je velika raznovrsnost in vitro istraživanja o utjecaju izoliranih vinskih fenola na koštani sustav, ali sa očitim manjkom dokaza o njihovoj in vivo djelotvornosti. Pregledom literature nisu pronađeni čvrsti dokazi koji pokazuju kako vino, kao mješavina fenola otopljenih u alkoholu utječe na koštani sustav, a što je značajnije jer se ono na taj način unosi i djeluje u organizmu. Naš sustavni pregled literature je pokazao manjkavost dosadašnjih radova o navedenom području te predložio daljnja usmjerena istraživanja.

Abstract (english)

A light-to-moderate wine consumption is shown to provide several beneficial effects on the skeletal system, including reduced risk of bone mass loss and fractures. Wine is rich in phenolic compounds, the strong phytoestrogens and natural antioxidants that are mainly attributed to the bone protection. The objective of this review was to give an overview of the exact mechanisms by which wine consumption is involved in bone protection. We found a great variety of in vitro research about beneficial effects of isolated wine phenolics on the skeletal system, with an evident lack of evidence of their in vivo effects. In addition, we found almost no studies to investigate how wine, a mixture of these phenolics dissolved in ethanol, affects the skeletal system. Our review showed deficiencies of previous research and gives suggestions for further research of this topic.

• Keywords: vino; fenoli; osteoblasti; osteoporoza
• Keywords (english): wine; phenolics; osteoblasts; osteoporosis
• Language: croatian
• URN:NBN: urn:nbn:hr:105:228324
• Study programme: Title: Orthopaedics and traumatology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/magistra ortopedije i traumatologije (sveučilišni/a magistar/magistra ortopedije i traumatologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-08-18 07:12:19