Povezanost kliničkih, laboratorijskih i termografskih nalaza u bolesnika s ulceroznim kolitisom

doctoral thesis

• Title (english): Association between clinical, laboratory and thermographic findings in patients with ulcerative colitis
• Author: Tonći Božin
• Mentor: Marko Banić (mentor)
• Committee member: Željko Krznarić (predsjednik povjerenstva)
• Committee member: Žarko Babić (član povjerenstva)
• Committee member: Neven Ljubičić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2020-07-01, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

UVOD: Cilj ovog istraživanja bio je prikazati dijagnostički potencijal infracrvene termografije kao neinvazivnog biomarkera aktivnosti ekstenzivnog ulceroznog kolitisa i njen potencijal u praćenju odgovora na terapiju. MATERIJALI I METODE: U istraživanje je uključeno 30 bolesnika s aktivnim ekstenzivnim kolitisom i 30 zdravih ispitanika. Bolesnici su praćeni tijekom šest mjeseci liječenja. Svi ispitanici su podvrgnuti termografskom snimanju kod uključivanja u istraživanje, a bolesnicima je nakon perioda praćenja ponovljeno termografsko snimanje. Termografski kriteriji (Tsred ROI 1 – 4) su komparirani među promatranim skupinama te komparirani s kliničkim, laboratorijskim i endoskopskim parametrima aktivnosti ulceroznog kolitisa. REZULTATI: Dokumentirane su značajno više temperature u termogramu bolesnika s aktivnim ulceroznim kolitisom u odnosu na temperature u termogramu zdravih ispitanika kao i u bolesnika koji nisu postigli remisiju u odnosu na bolesnike u remisiji. Zabilježena je povezanost srednjaka temperatura i kliničkih (Mayo), laboratorijskih (FC, CRP) i endoskopskog nalaza (Mayo ESS) u skupini bolesnika s ulceroznim kolitisom. ZAKLJUČAK: Statična termografija abdomena pokazuje potencijal u dijagnostici i praćenju bolesnika s ekstenzivnim ulceroznim kolitisom.

Abstract (english)

INTRODUCTION: The aim of this paper was to describe the diagnostic potential of thermography in surveillance and as a noninvasive biomarker of disease activity in patients with extensive ulcerative colitis. MATERIAL AND METHODS: 30 patients with active extensive colitis and 30 healthy subjects where enrolled in the study. Patients where prospectively followed and treated for 6 months. All of the participants where subject to infrared thermography at enrollment but UC patients were screened once more after 6 months. Thermographic criteria (Tsred ROI 1 – 4) where compared among the two groups of participants but also compared to standard clinical, laboratory and endoscopic markers of disease activity. RESULTS: higher temperatures were observed among patients with active ulcerative colitis compared to healthy subjects as well as in patients with active disease compared to those in remission after 6 months. Statistically significant correlation was observed between average abdominal temperatures and clinical (Mayo score), laboratory (FC, CRP) and endoscopic findings (Mayo ESS) in patients with ulcerative colitis. CONCLUSION: This paper depicts static abdominal thermography as a potential noninvasive tool for screening and surveillance of patients with extensive ulcerative colitis.

• Keywords: ulcerozni kolitis; termografija; Mayo indeks; fekalni kalprotektin
• Keywords (english): ulcerative colitis; thermography; Mayo index; fecal calprotectin
• Language: croatian
• URN:NBN: urn:nbn:hr:105:581730
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Catalog URL: https://katalog.nsk.hr/F/19IT7Y755V1NXQJPHCLYSQGPF6BLAPPF179HQ7FAXXMYBYGMV5-19784?func=find-e&request=Povezanost+klini%C4%8Dkih%2C+laboratorijskih+i+termografskih+nalaza+u+bolesnika+s+ulceroznim+kolitisom&find_scan_code=FIND_NAS&adjacent=N&local_base=MF_WEB&x=14&y=18&filter_code_1=WLN&filter_request_1=&filter_code_2=WYR&filter_request_2=&filter_code_3=WYR&filter_request_3=&filter_code_4=WFM&filter_request_4=
• Type of resource: Text
• Extent: 112 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-10-26 11:40:39