Vrijednost dodatnoga ultrazvučnog pregleda nakon magnetskom rezonancijom otkrivene sumnjive promjene u dojci

Scientific paper - Original scientific paper

• Title (english): Value of second-look ultrasound of suspicious breast lesion detected on MRI
• Author: Lora Grbanović
• Author: Marko Petrovečki
• Author: Sanja Barišić Ostojić
• Author: Vlatko Duspara
• Author: Maja Prutki
• Author's institution: University of Zagreb; School of Medicine; (Department of Radiology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiology

Abstract (croatian)

Cilj. Svrha ovog rada jest utvrditi kliničku vrijednost dodatnoga ultrazvučnog (UZV) pregleda u evaluaciji
sumnjivih lezija dojke inicijalno otkrivenih na pregledu magnetskom rezonancijom (MR) u pacijentica s
invazivnim karcinomom dojke. Ispitanici i metode. Ovo retrospektivno istraživanje provedeno je analizom radioloških
nalaza 277 bolesnica s karcinomom dojke kojima je u sklopu preoperativne obrade učinjen pregled MR-om
na Kliničkom zavodu za dijagnostičku i intervencijsku radiologiju Kliničkoga bolničkog centra Zagreb. Na pregledu
MR-om otkrivene su nove lezije koje su dodatno analizirane na ciljanom, dodatnom UZV pregledu. Učinjena je
biopsija širokom iglom ili citološka punkcija UZV-om otkrivenih sumnjivih lezija kako bi se učinila patohistološka,
odnosno citološka analiza. Uspoređena je korelacija MR i UZV nalaza s obzirom na tip i veličinu lezije. Rezultati.
Preoperativnim MR pregledom otkrivene su 33 nove lezije. Dodatnim UZV pregledom verificirano je 25 lezija
(75,8%), od kojih je 10 lezija (40,0%) pokazivalo benigne karakteristike. Zbog suspektnih obilježja kod 15 lezija
(60,0%) učinjena je patohistološka ili citološka analiza. Među lezijama koje su ultrazvučno verificirane ukupno je
otkriveno devet (36,0%) karcinoma i 16 lezija (64,0%) benignih karakteristika. Nije zabilježen niti jedan slučaj
karcinoma tijekom dvogodišnjeg praćenja lezija benignih karakteristika. Postotak korelacije UZV i MR nalaza značajno
je veći za lezije koje su se na MR-u prikazale kao tvorbe u usporedbi s korelacijom za zone imbibicije
(p<0,05). Za fokus imbibicije nije zabilježena niti jedna korelacija. Veličina tvorbi i zona imbibicije ne utječe na
uspjeh korelacije. Zaključak. Sumnjive lezije otkrivene MR-om mogu se analizirati dodatnim UZV pregledom,
odnosno postotak korelacije UZV i MR nalaza je visok, pri čemu tvorbe pokazuju viši postotak korelacije od zona
imbibicije. Za tvorbe i zone imbibicije veličina nema utjecaja na uspjeh korelacije. Dodatni UZV koristan je dodatak
dijagnostičkoj obradi pacijentica s MR-om otkrivenom lezijom u dojci te se njegovom uporabom mogu izbjeći
nepotrebne biopsije.

Abstract (english)

Aim. The purpose of this study is to determine the clinical utility of an additional ultrasound examination
in the evaluation of suspicious breast lesions detected initially on magnetic resonance imaging (MRI) in the
patients with invasive breast cancer. Patients and Methods. This retrospective study was conducted by analysing
the radiology reports of 277 patients with breast cancer who underwent MRI as a part of the preoperative workup
at the University Hospital Centre Zagreb, Department of Radiology. MRI scan detected new lesions were subsequently
evaluated by ultrasound examination. Percutaneous biopsy or fine needle aspiration (FNA) was performed
on suspicious lesions to obtain pathohistological or cytological confirmation. Correlation of MRI and
ultrasound findings was compared with respect to the lesion type and size. Results. A total of 33 new lesions were
detected on preoperative MRI. Ultrasound correlation was made in 25 lesions (75.8%). Ten lesions (40.0%) had
benign characteristics. Fifteen lesions (60.0%) underwent biopsy or FNA. In total, nine lesions (36.0%) were
confirmed as malignant and 16 (64.0%) had benign characteristics. There was no recorded case of carcinoma in
the group of lesions with benign appearance that were followed up for two years. Correlation rate of MRI and
ultrasound findings was significantly higher in mass lesions (p<0.05). No correlation was found for foci. The size
of other lesions did not affect correlation rate. Conclusion. Suspicious lesions detected on MRI can be successfully
analysed on additional ultrasound examination. Correlation rate of MRI and ultrasound findings is high, with mass
lesions exhibiting a higher percentage of correlation than non-mass lesions. The size of those lesions does not
affect correlation rate. Additional ultrasound is useful in diagnostic workup of patients with MRI-detected breast
lesion and can reduce the number of unnecessary biopsies.

• Keywords (croatian): TUMORI DOJKE – dijagnostički slikovni prikaz, patologija; ULTRAZVUK DOJKE; MAGNETSKA REZONANCIJA; BIOPSIJA ŠIROKOM IGLOM; CITOLOŠKA PUNKCIJA POD KONTROLOM ULTRAZVUKA; OSJETLJIVOST I SPECIFIČNOST; RETROSPEKTIVNA ISTRAŽIVANJA
• Keywords (english): BREAST NEOPLASMS – diagnostic imaging, pathology; ULTRASONOGRAPHY, MAMMARY; MAGNETIC RESONANCE IMAGING; BIOPSY, LARGE-CORE NEEDLE; ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION; SENSITIVITY AND SPECIFICITY; RETROSPECTIVE STUDIES
• Language: croatian
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Liječnički vjesnik
• Numbering: vol. 142, no. 7-8, pp. 199-203
• p-ISSN: 0024-3477
• e-ISSN: 1849-2177
• DOI: https://doi.org/10.26800/LV-142-7-8-33
• URN:NBN: urn:nbn:hr:105:350471
• Publication: 2020
• Document URL: https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=353462
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-11-26 11:57:30