prikaz prve stranice dokumenta Autonomic dysfunction in people with neuromyelitis optica spectrum disorders
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Scientific paper - Original scientific paper
Autonomic dysfunction in people with neuromyelitis optica spectrum disorders
Multiple Sclerosis Journal, 26 (2020), 6; 688-695. https://doi.org/10.1177/1352458519837703
Crnošija, Luka; Krbot Skorić, Magdalena; Andabaka, Marko; Junaković, Anamari; Martinović, Vanja; Ivanović, Jovana; Mesaroš, Šarlota; Pekmezović, Tatjana; Drulović, Jelena; Habek, Mario

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Crnošija, L., Krbot Skorić, M., Andabaka, M., Junaković, A., Martinović, V., Ivanović, J. ... Habek, M. (2020). Autonomic dysfunction in people with neuromyelitis optica spectrum disorders. Multiple Sclerosis Journal, 26. (6), 688-695. doi: 10.1177/1352458519837703

Crnošija, Luka, et al. "Autonomic dysfunction in people with neuromyelitis optica spectrum disorders." Multiple Sclerosis Journal, vol. 26, no. 6, 2020, pp. 688-695. https://doi.org/10.1177/1352458519837703

Crnošija, Luka, Magdalena Krbot Skorić, Marko Andabaka, Anamari Junaković, Vanja Martinović, Jovana Ivanović, Šarlota Mesaroš, Tatjana Pekmezović, Jelena Drulović and Mario Habek. "Autonomic dysfunction in people with neuromyelitis optica spectrum disorders." Multiple Sclerosis Journal 26, no. 6 (2020): 688-695. https://doi.org/10.1177/1352458519837703

Crnošija, L., et al. (2020) 'Autonomic dysfunction in people with neuromyelitis optica spectrum disorders', Multiple Sclerosis Journal, 26(6), pp. 688-695. doi: 10.1177/1352458519837703

Crnošija L, Krbot Skorić M, Andabaka M, Junaković A, Martinović V, Ivanović J, and sur.. Autonomic dysfunction in people with neuromyelitis optica spectrum disorders. Multiple Sclerosis Journal [Internet]. 2020 May [cited 2024 September 18];26(6):688-695. doi: 10.1177/1352458519837703

L. Crnošija, et al., "Autonomic dysfunction in people with neuromyelitis optica spectrum disorders", Multiple Sclerosis Journal, vol. 26, no. 6, pp. 688-695, May 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:997279. [Accessed: 18 September 2024]

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Metadata
Title (english)Autonomic dysfunction in people with neuromyelitis optica spectrum disorders
AuthorLuka Crnošija
AuthorMagdalena Krbot Skorić
AuthorMarko Andabaka
AuthorAnamari Junaković
AuthorVanja Martinović
AuthorJovana Ivanović
AuthorŠarlota Mesaroš
AuthorTatjana Pekmezović
AuthorJelena Drulović
AuthorMario Habek
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Aims: To determine the difference in autonomic symptom burden measured with the Composite Autonomic System Score-31 (COMPASS-31) and presence of objective dysautonomia in people with neuromyelitis optica spectrum disorders (pwNMOSD) compared to people with multiple sclerosis (pwMS). ----- Design/methods: Twenty pwNMOSD and 20 pwMS, matched for age, sex, and disease duration, were enrolled. All patients completed the COMPASS-31. The quantification of cardiovascular autonomic dysfunction (CAD) was made using the two indices of the Composite Autonomic Scoring Scale (CASS): adrenergic index (AI) and cardiovagal index (CI). ----- Results: In all pwNMOSD, COMPASS-31 was >0. Sympathetic dysfunction was present in 8 (40%), parasympathetic dysfunction in 10 (50%), and orthostatic hypotension in 6 (30%) pwNMOSD. This group of patients had higher frequency and level on the pupillomotor domain of the COMPASS-31 compared to pwMS (p = 0.048 and p = 0.006, respectively). A binary logistic regression model showed that drop in diastolic blood pressure (dBP) during tilt-table test and normal function of autonomic nervous system, defined as AI = 0 and CI = 0, were independent predictors of pwNMOSD (p = 0.042 and p = 0.029, respectively). If CAD was present, it was significantly worse in pwNMOSD compared to pwMS (p = 0.003). ----- Conclusion: Significant proportion of pwNMOSD experience dysautonomia, which seems to be different from dysautonomia observed in pwMS.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMultiple Sclerosis Journal
Numberingvol. 26, no. 6, pp. 688-695
p-ISSN1352-4585
e-ISSN1477-0970
DOIhttps://doi.org/10.1177/1352458519837703
URN:NBNurn:nbn:hr:105:997279
Publication2020-05
Document URLhttp://journals.sagepub.com/doi/10.1177/1352458519837703
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2021-05-31
Terms of useLicence In copyright icon
Created on2021-01-18 12:29:47